Table 5. Glossary of effectors:... | Rockefeller University Press

Table 5.

Glossary of effectors: Bacterial manipulation of host ubiquitination pathways

Bacteria	Effector	Host target	Target pathways	Outcome	Mode of action	Reference
L. pneumophila	SidE effector family	Rabs; Reticulon 4	UbDCP^{^a}	Inhibition of mitophagy,^{^b} innate immunity,^{^b} proteasomal degradation,^{^b} membrane trafficking, ER structure	Ubiquitin ligase/DUB	Sheedlo et al., 2015; Bhogaraju et al., 2016; Qiu et al., 2016; Kotewicz et al., 2017
L. pneumophila	SidJ	SidE-ubiquitinated substrates; host-ubiquitinated substrates	UbDCP	Removes ubiquitination left by the host as well as from SidE effector family	DUB	Qiu et al., 2017

Bacteria	Effector	Host target	Target pathways	Outcome	Mode of action	Reference
L. pneumophila	SidE effector family	Rabs; Reticulon 4	UbDCP^a	Inhibition of mitophagy,^b innate immunity,^b proteasomal degradation,^b membrane trafficking, ER structure	Ubiquitin ligase/DUB	Sheedlo et al., 2015; Bhogaraju et al., 2016; Qiu et al., 2016; Kotewicz et al., 2017
L. pneumophila	SidJ	SidE-ubiquitinated substrates; host-ubiquitinated substrates	UbDCP	Removes ubiquitination left by the host as well as from SidE effector family	DUB	Qiu et al., 2017

UbDCP, ubiquitination-dependent cellular processes.

Results from overexpression of SidE effector family member.