Table 3. Glossary of effectors:... | Rockefeller University Press

Table 3.

Glossary of effectors: Bacterial modulation of the UPR

Bacteria	Effector	Host target	Target pathways	Outcome	Mode of action	Reference
B. melitensis	TcpB	Unknown	ATF6, PERK, IRE1	Activation of the UPR	Unknown	Smith et al., 2013
B. abortus	VceC	BiP	IRE1	Activation of the UPR	Unknown	de Jong et al., 2013; Keestra-Gounder et al., 2016
L. monocytogenes	LLO	Unknown	ATF6, PERK, IRE1	Activation of the UPR	Unknown	Pillich et al., 2012
L. pneumophila	Lgt1, Lgt2, Lgt3	Unknown	IRE1	Inhibition of XBP1u mRNA splicing	Glucosyltransferase	Hempstead and Isberg, 2015; Treacy-Abarca and Mukherjee, 2015

Bacteria	Effector	Host target	Target pathways	Outcome	Mode of action	Reference
B. melitensis	TcpB	Unknown	ATF6, PERK, IRE1	Activation of the UPR	Unknown	Smith et al., 2013
B. abortus	VceC	BiP	IRE1	Activation of the UPR	Unknown	de Jong et al., 2013; Keestra-Gounder et al., 2016
L. monocytogenes	LLO	Unknown	ATF6, PERK, IRE1	Activation of the UPR	Unknown	Pillich et al., 2012
L. pneumophila	Lgt1, Lgt2, Lgt3	Unknown	IRE1	Inhibition of XBP1u mRNA splicing	Glucosyltransferase	Hempstead and Isberg, 2015; Treacy-Abarca and Mukherjee, 2015