Table 1. Gene KD resulting in decreased... | Rockefeller University Press

Table 1.

Gene KD resulting in decreased transport phenotype

Gene Rank	Gene name	Z-score	Reason for inclusion in screen
1^{^a}	ACTR3B	−5.41	Literature
2^{^a}	EXOC2	−5.38	Literature
3^{^a}	ARL14	−5.33	Expression, domain
4	EXOC7	−4.85	Literature
5^{^a}	PARD6B	−4.78	Expression, phenotype
6	EXOC8	−4.64	Literature
7^{^a}	VPS13C	−4.47	Localization, domain, phenotype
8^{^a}	CCZ1	−4.15	Localization, domain
9	GNAS	−4.08	Localization, domain, phenotype
10^{^a}	LEPROT	−3.89	Localization, domain
11	EXOC5	−3.87	Literature
12	STAM	−3.75	Localization, domain
13	DYNC1H1	−3.58	Localization, domain, phenotype
14	DYNC1LI1	−3.52	Phenotype, domain
15^{^a}	ARMT1	−3.51	Expression, phenotype
16	STX19	−3.48	Localization, domain
17	LRRK2	−3.37	Phenotype, domain
18	RAB10	−3.30	Localization, domain, phenotype
19	VPS26A	−3.29	Localization, domain
20	SNX27	−3.22	Localization, domain
21	TRIP11	−3.19	Phenotype, domain
22	TMED2	−3.16	Localization, domain
23	ROCK1	−3.01	Phenotype, domain

Gene Rank	Gene name	Z-score	Reason for inclusion in screen
1^{^a}	ACTR3B	−5.41	Literature
2^{^a}	EXOC2	−5.38	Literature
3^{^a}	ARL14	−5.33	Expression, domain
4	EXOC7	−4.85	Literature
5^{^a}	PARD6B	−4.78	Expression, phenotype
6	EXOC8	−4.64	Literature
7^{^a}	VPS13C	−4.47	Localization, domain, phenotype
8^{^a}	CCZ1	−4.15	Localization, domain
9	GNAS	−4.08	Localization, domain, phenotype
10^{^a}	LEPROT	−3.89	Localization, domain
11	EXOC5	−3.87	Literature
12	STAM	−3.75	Localization, domain
13	DYNC1H1	−3.58	Localization, domain, phenotype
14	DYNC1LI1	−3.52	Phenotype, domain
15^{^a}	ARMT1	−3.51	Expression, phenotype
16	STX19	−3.48	Localization, domain
17	LRRK2	−3.37	Phenotype, domain
18	RAB10	−3.30	Localization, domain, phenotype
19	VPS26A	−3.29	Localization, domain
20	SNX27	−3.22	Localization, domain
21	TRIP11	−3.19	Phenotype, domain
22	TMED2	−3.16	Localization, domain
23	ROCK1	−3.01	Phenotype, domain

Genes selected for secondary validation.