Table 1.
Genes induced by nuclear calcium signaling (i.e., down-regulated by CaMBP4) with a role in T cell activation
SignalingMAPKs pathwayTranscription
PRKCQ (PKCθ) MAP4K2 STAT2 
PLCG2 (PLCγ2) RASGRP3 SMAD3 
Receptors IFN signaling SMAD4 
CD27 IFITM SMAD7 
CD8A IRF8 FOXO1 
IL-2R IFI27 EOMES 
TGFβ R IRFI35  
Cytokines Inflammation and cytotoxic activity Adhesion molecules 
IFNγ KLRD1 (CD94) ITGB2 
IL-2 KLRB1 ITGAL 
IL-3 GZMA (granzyme) ICAM3 
IL-4 GZMK (granzyme) ITGB7 
GM-CSF (CSF2) GZMH (granzyme) Rho GTPase signaling 
TNFSF13B (BAFF) PTGER2 RAP-GEF 
TNFSF10  ARHGAP4 
SignalingMAPKs pathwayTranscription
PRKCQ (PKCθ) MAP4K2 STAT2 
PLCG2 (PLCγ2) RASGRP3 SMAD3 
Receptors IFN signaling SMAD4 
CD27 IFITM SMAD7 
CD8A IRF8 FOXO1 
IL-2R IFI27 EOMES 
TGFβ R IRFI35  
Cytokines Inflammation and cytotoxic activity Adhesion molecules 
IFNγ KLRD1 (CD94) ITGB2 
IL-2 KLRB1 ITGAL 
IL-3 GZMA (granzyme) ICAM3 
IL-4 GZMK (granzyme) ITGB7 
GM-CSF (CSF2) GZMH (granzyme) Rho GTPase signaling 
TNFSF13B (BAFF) PTGER2 RAP-GEF 
TNFSF10  ARHGAP4 
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