Table 2.

Ylr072w/Ltc1 interacts with proteins on mitochondria and vacuoles

Identified protein Average spectral counts Description CRAPome score 
 WT Δtom70 Δtom71   
Ylr072w/Ltc1 280.5 242.5 – 0.00 
Tom71 53 Mitochondrial protein import receptor 0.00 
Tom70 13 Mitochondrial protein import receptor 0.00 
Vac8 11.5 22.5 Multifunctional vacuolar protein 0.00 
Gem1 10.5 Miro GTPase 0.00 
Mdm34 ERMES subunit 0.00 
Leu9 Leucine biosynthesis; mitochondrial 0.00 
Npr1 Protein kinase; substrate of TORC1 0.00 
Erj5 ER-localized J protein 0.00 
Ybt1 1.5 Vacuole-localized ABC transporter 0.00 
Mam33 12.5 Mitochondrial matrix acidic protein 0.00 
Pdr10 5.5 ABC transporter 0.00 
Erg6 Ergosterol biosynthesis 0.11 
Kog1 1.5 5.5 Subunit of TORC1 0.11 
Mnp1 7.5 Mitochondrial nucleoid protein 0.17 
Vph1 4.5 14 Vacuolar ATPase subunit 0.22 
Identified protein Average spectral counts Description CRAPome score 
 WT Δtom70 Δtom71   
Ylr072w/Ltc1 280.5 242.5 – 0.00 
Tom71 53 Mitochondrial protein import receptor 0.00 
Tom70 13 Mitochondrial protein import receptor 0.00 
Vac8 11.5 22.5 Multifunctional vacuolar protein 0.00 
Gem1 10.5 Miro GTPase 0.00 
Mdm34 ERMES subunit 0.00 
Leu9 Leucine biosynthesis; mitochondrial 0.00 
Npr1 Protein kinase; substrate of TORC1 0.00 
Erj5 ER-localized J protein 0.00 
Ybt1 1.5 Vacuole-localized ABC transporter 0.00 
Mam33 12.5 Mitochondrial matrix acidic protein 0.00 
Pdr10 5.5 ABC transporter 0.00 
Erg6 Ergosterol biosynthesis 0.11 
Kog1 1.5 5.5 Subunit of TORC1 0.11 
Mnp1 7.5 Mitochondrial nucleoid protein 0.17 
Vph1 4.5 14 Vacuolar ATPase subunit 0.22 

Ylr072w/Ltc1-yEGFP was purified from yeast WT or Δtom70 Δtom71 cell lysates, and proteins were identified by tandem mass spectrometry with a <1% false discovery rate. Control mock purifications were performed from isogenic strain backgrounds that did not express yEGFP. The average total spectral counts assigned to each protein from two independent experiments are tabulated. Tabulated are proteins that were identified in duplicate sample experiments and whose average spectral counts were at least 10-fold higher than in mock purifications. The “CRAPome” score for identified proteins is listed at right and was measured as in Table 1.

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