Components of the yeast E3 ligase complexes and their mammalian counterparts
| Component | Function | Mammalian homologue |
| Hrd1 complex | ||
| Hrd1 | E3 ligase activity/retrotranslocation? | HRD1, gp78 |
| Hrd3 | Substrate recognition, Hrd1 stability | SEL1 |
| Yos9 | Substrate recognition | OS9, XTP3-B |
| Kar2 | Chaperone activity, substrate recognition | Bip |
| Usa1 | Hrd1 and Der1 oligomerization | HERP |
| Der1 | Recognition/transfer of substrate to Hrd1/retrotranslocation? | Derlin-1, -2, -3 |
| Doa10 complex | ||
| Doa10 | E3 ligase activity | TEB4 |
| Ubc6 | E2 ubiquitin-conjugating activity | Ubc6, Ubc6e |
| Common to Hrd1 and Doa10 complexes | ||
| Ubc7 | E2 ubiquitin-conjugating activity | UBE2G1, UBE2G2 |
| Cue1 | Recruitment and activation of Ubc7 | |
| Ubx2 | Membrane-recruiting factor for Cdc48 | UBXD8 |
| Cdc48 | Substrate retrotranslocation and membrane extraction | p97/VCP |
| Npl4 | Cdc48 cofactor | NPL4 |
| Ufd1 | Cdc48 cofactor | UFD1 |
| Component | Function | Mammalian homologue |
| Hrd1 complex | ||
| Hrd1 | E3 ligase activity/retrotranslocation? | HRD1, gp78 |
| Hrd3 | Substrate recognition, Hrd1 stability | SEL1 |
| Yos9 | Substrate recognition | OS9, XTP3-B |
| Kar2 | Chaperone activity, substrate recognition | Bip |
| Usa1 | Hrd1 and Der1 oligomerization | HERP |
| Der1 | Recognition/transfer of substrate to Hrd1/retrotranslocation? | Derlin-1, -2, -3 |
| Doa10 complex | ||
| Doa10 | E3 ligase activity | TEB4 |
| Ubc6 | E2 ubiquitin-conjugating activity | Ubc6, Ubc6e |
| Common to Hrd1 and Doa10 complexes | ||
| Ubc7 | E2 ubiquitin-conjugating activity | UBE2G1, UBE2G2 |
| Cue1 | Recruitment and activation of Ubc7 | |
| Ubx2 | Membrane-recruiting factor for Cdc48 | UBXD8 |
| Cdc48 | Substrate retrotranslocation and membrane extraction | p97/VCP |
| Npl4 | Cdc48 cofactor | NPL4 |
| Ufd1 | Cdc48 cofactor | UFD1 |