Parameters for NE targeting dynamics used for modeling-based analysis
| Model parameters | ER fractions | k2m | k34 (ONM → INM)a | INM fractions | k4b | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mobile | Immobile | Optimum | Optimum | Range (95% CI) | Mobile | Immobile | Value | |||||
| min−1 | min−1 | min−1 | min−1 | |||||||||
| LBR(1-245) | 0.92 | 0.08 | 1.890 | 1.30 | 0.90-1.98 | 0.009 | 0.991 | 2.76 | ||||
| LAP2β | 0.93 | 0.07 | 1.890 | 0.40 | 0.31-0.50 | 0.025 | 0.975 | 2.04 | ||||
| SUN2(fl) | 0.88 | 0.12 | 0.006 | 0.29 | 0.14–1.14 | 0.026 | 0.974 | 1.94 | ||||
| SUN2(1-260) | 0.95 | 0.05 | 4.456 | 1.39 | 0.90-2.20 | 0.112 | 0.888 | 1.46 | ||||
| Mobile | Immobile | Optimum | Optimum | Range (95% CI) | Mobile | Immobile | Value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LBR(1-245) | 1.890 | 1.30 | 0.90-1.98 | |||||||||
| LAP2β | 1.890 | 0.40 | 0.31-0.50 | |||||||||
| SUN2(fl) | 0.006 | 0.29 | 0.14–1.14 | |||||||||
| SUN2(1-260) | 4.456 | 1.39 | 0.90-2.20 | |||||||||
Italics indicate values derived from measurements. CI, confidence interval.
k34 = k43.