Guidance cues and local protein synthesis
| Guidance cue | Receptor | Effect on protein synthesis | Target mRNA involved in axon guidnace | Response mediated by protein synthesis | Neuron type | Reference |
| Netrin1 | DCC, UNC-5 | Induce | β-actin | Attractive | RGC | Campbell and Holt, 2001; Leung et al., 2006; Yao et al., 2006; Welshhans and Bassell, 2011 |
| Sema3A | Neuropilin1, PlexinA | Induce | Rho A NFPC | Repulsive Caudal turn | DRG RGC | Campbell and Holt, 2001; Wu et al., 2005; Leung et al., 2013 |
| Slit2 | Robo3 | Induce | Cofilin | Repulsive | RGC | Campbell and Holt, 2001; Piper et al., 2006 |
| Ephrin A | EphA | Suppress | ND | Repulsive | RGC | Nie et al., 2010 |
| Ephrin B | EphB | None | None | None | RGC | Mann et al., 2003 |
| Engrailed | ND | Induce | ND | Attractive, Repulsive | RGC | Brunet et al., 2005 |
| BDNF | TrkB | Induce | β-actin | Attractive, Repulsive | Spinal, hippocampal, and cortical | Zhang et al., 1999; Yao et al., 2006; Sasaki et al., 2010 |
| SFRP1 | Fz2 | Induce | ND | Attractive | RGC | Rodriguez et al., 2005 |
| NGF | TrkA | Induce | Par3, β-actin WAVE1, cortactin, Arp2 | ElongationBranching | RGCDRG | Hengst et al., 2009 ,Spillane et al., 2012 |
| CSPGs | NgR1, 3 | Induce | Rho A | Axonal growth inhibition | DRG | Dickendesher et al., 2012; Walker et al., 2012 |
| Guidance cue | Receptor | Effect on protein synthesis | Target mRNA involved in axon guidnace | Response mediated by protein synthesis | Neuron type | Reference |
| Netrin1 | DCC, UNC-5 | Induce | β-actin | Attractive | RGC | Campbell and Holt, 2001; Leung et al., 2006; Yao et al., 2006; Welshhans and Bassell, 2011 |
| Sema3A | Neuropilin1, PlexinA | Induce | Rho A NFPC | Repulsive Caudal turn | DRG RGC | Campbell and Holt, 2001; Wu et al., 2005; Leung et al., 2013 |
| Slit2 | Robo3 | Induce | Cofilin | Repulsive | RGC | Campbell and Holt, 2001; Piper et al., 2006 |
| Ephrin A | EphA | Suppress | ND | Repulsive | RGC | Nie et al., 2010 |
| Ephrin B | EphB | None | None | None | RGC | Mann et al., 2003 |
| Engrailed | ND | Induce | ND | Attractive, Repulsive | RGC | Brunet et al., 2005 |
| BDNF | TrkB | Induce | β-actin | Attractive, Repulsive | Spinal, hippocampal, and cortical | Zhang et al., 1999; Yao et al., 2006; Sasaki et al., 2010 |
| SFRP1 | Fz2 | Induce | ND | Attractive | RGC | Rodriguez et al., 2005 |
| NGF | TrkA | Induce | Par3, β-actin WAVE1, cortactin, Arp2 | ElongationBranching | RGCDRG | Hengst et al., 2009 ,Spillane et al., 2012 |
| CSPGs | NgR1, 3 | Induce | Rho A | Axonal growth inhibition | DRG | Dickendesher et al., 2012; Walker et al., 2012 |
BDNF, brain-derived neurotrophic factor; SFRP1, secreted frizzled-related protein 1; NFPC, NF-protocadherin; NGF, nerve growth factor; CSPGs, chondroitin sulfate proteoglycans; RGC, retinal ganglion cell; DRG, dorsal root ganglion neuron ND, not determined.