Table 1. Comparison of model predictions... | Rockefeller University Press

Table 1.

Comparison of model predictions and experimental outcomes

Attributes	Experimental	Minimal linear stochastic	Coupled linear stochastic	Coupled nonlinear stochastic	Coupled nonlinear stochastic + cross-links
Outward motor force		Poisson	On/off rates	On/off rates	On/off rates
Inward spring force		Hookean	Hookean	Piecewise continuous	Piecewise continuous
kMT dynamics		Gaussian	Gardner et al., 2005	Gardner et al., 2005	Gardner et al., 2005
Spring network		Individual	Individual	Individual	Cross-linked network
Measurable attributes	Perturbation of the chromatin spring
Spindle length	Increases	Increases	Increases	Increases	Increases
Spindle variation	Increases	Increases	Increases	Increases	Increases
Chromatin stretching	Increases	NM	NM	Increases	Increases
Kinetochore declustering	Increases	NM	Constant	Increases	Increases
Coordinated stretching	~40% WT	Not predicted	Not predicted	Not predicted	Predicted

Attributes	Experimental	Minimal linear stochastic	Coupled linear stochastic	Coupled nonlinear stochastic	Coupled nonlinear stochastic + cross-links
Outward motor force		Poisson	On/off rates	On/off rates	On/off rates
Inward spring force		Hookean	Hookean	Piecewise continuous	Piecewise continuous
kMT dynamics		Gaussian	Gardner et al., 2005	Gardner et al., 2005	Gardner et al., 2005
Spring network		Individual	Individual	Individual	Cross-linked network
Measurable attributes	Perturbation of the chromatin spring
Spindle length	Increases	Increases	Increases	Increases	Increases
Spindle variation	Increases	Increases	Increases	Increases	Increases
Chromatin stretching	Increases	NM	NM	Increases	Increases
Kinetochore declustering	Increases	NM	Constant	Increases	Increases
Coordinated stretching	~40% WT	Not predicted	Not predicted	Not predicted	Predicted

NM, not measureable.