Properties and localization of PAR degrading enzymes
| Gene name | Alternative name | Cleave ribose–ribose bonds? | Cleave between ADP-ribose and acidic residues? | Localization |
| PARG | + | − | Cytoplasm, nucleus, mitochondria | |
| ARH3 | ADPRHL2 | + | Not tested | Cytoplasm, nucleus, mitochondria |
| MacroD1 | LRP16 | − | + | Cytoplasm, nucleus |
| MacroD2 | C20orf133 | − | + | Cytoplasm, nucleus |
| TARG1 | C6orf130, OARD1 | − | + | Cytoplasm, nucleus |
| Gene name | Alternative name | Cleave ribose–ribose bonds? | Cleave between ADP-ribose and acidic residues? | Localization |
| PARG | + | − | Cytoplasm, nucleus, mitochondria | |
| ARH3 | ADPRHL2 | + | Not tested | Cytoplasm, nucleus, mitochondria |
| MacroD1 | LRP16 | − | + | Cytoplasm, nucleus |
| MacroD2 | C20orf133 | − | + | Cytoplasm, nucleus |
| TARG1 | C6orf130, OARD1 | − | + | Cytoplasm, nucleus |
ARH3, ADP-ribosylhydrolase 3; PARG, poly(ADP-ribose) glycohydrolase; TARG1, terminal ADP-ribose protein glycohydrolase 1.