Table 1.

Activities and localization of PARPs

Gene name Alternative name Activity Localization 
PARP-1 ARTD1 PARylation (branching) Nucleus, nucleoli 
PARP-2 ARTD2 PARylation Cytoplasmic puncta, nuclear puncta, nucleoli 
PARP-3 ARTD3 MARylation/PARylation? Cytoplasmic puncta, nuclear puncta 
PARP-4 ARTD4 PARylation Cytoplasmic puncta and nucleus 
PARP-5a ARTD5, TNKS PARylation Cytoplasmic puncta, centrosome, stress granules, spindle pole 
PARP-5b ARTD6, TNKS2 PARylation Cytoplasmic puncta, spindle 
PARP-6 ARTD17 MARylation? Cytoplasmic puncta 
PARP-7 ARTD14, tiPARP MARylation? Cytoplasmic puncta, nuclear puncta 
PARP-8 ARTD16 MARylation? Cytoplasmic puncta, centrosome, nuclear envelope, spindle pole 
PARP-9 ARTD9, BAL1 Inactive Cytoplasm, plasma membrane, nucleus 
PARP-10 ARTD10 MARylation Cytoplasmic puncta 
PARP-11 ARTD11 MARylation? Cytoplasmic puncta, nuclear puncta, centriole 
PARP-12 ARTD12, ZC3HDC1 MARylation Cytoplasmic puncta, Golgi, stress granules 
PARP-13 ARTD13, ZC3HAV1, ZAP Inactive Cytoplasmic puncta, stress granules 
PARP-14 ARTD8, BAL2, CoaSt6 MARylation Cytoplasmic puncta, nuclear puncta, focal adhesion, stress granules 
PARP-15 ARTD7, BAL3 MARylation? Stress granules 
PARP-16 ARTD15 MARylation Cytoplasmic puncta, reticular 
Gene name Alternative name Activity Localization 
PARP-1 ARTD1 PARylation (branching) Nucleus, nucleoli 
PARP-2 ARTD2 PARylation Cytoplasmic puncta, nuclear puncta, nucleoli 
PARP-3 ARTD3 MARylation/PARylation? Cytoplasmic puncta, nuclear puncta 
PARP-4 ARTD4 PARylation Cytoplasmic puncta and nucleus 
PARP-5a ARTD5, TNKS PARylation Cytoplasmic puncta, centrosome, stress granules, spindle pole 
PARP-5b ARTD6, TNKS2 PARylation Cytoplasmic puncta, spindle 
PARP-6 ARTD17 MARylation? Cytoplasmic puncta 
PARP-7 ARTD14, tiPARP MARylation? Cytoplasmic puncta, nuclear puncta 
PARP-8 ARTD16 MARylation? Cytoplasmic puncta, centrosome, nuclear envelope, spindle pole 
PARP-9 ARTD9, BAL1 Inactive Cytoplasm, plasma membrane, nucleus 
PARP-10 ARTD10 MARylation Cytoplasmic puncta 
PARP-11 ARTD11 MARylation? Cytoplasmic puncta, nuclear puncta, centriole 
PARP-12 ARTD12, ZC3HDC1 MARylation Cytoplasmic puncta, Golgi, stress granules 
PARP-13 ARTD13, ZC3HAV1, ZAP Inactive Cytoplasmic puncta, stress granules 
PARP-14 ARTD8, BAL2, CoaSt6 MARylation Cytoplasmic puncta, nuclear puncta, focal adhesion, stress granules 
PARP-15 ARTD7, BAL3 MARylation? Stress granules 
PARP-16 ARTD15 MARylation Cytoplasmic puncta, reticular 

PARylation, poly(ADP-ribosyl)ation; MARylation, mono(ADP-ribosyl)ation. Predicted activities are indicated with question marks. Localization data are based on Meder et al. (2005); Leung et al. (2011); and Vyas et al. (2013).

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