Adaptor and accessory proteins involved in endocytosis
| Mammalian protein | Yeast homologue | Lipid-binding domain | Clathrin binding | Example of specific cargo uptake | Reference for cargo uptake |
| AP2 (α, β2, μ2, σ2) | AP2 (Apl3, Apl1, Apm4, Aps2) | α-Core domain and μ2 C-terminal domain | Yes | Transferrin receptor | Motley et al., 2003 |
| FCHo1/2 | Syp1 | F-BAR domain | – | Mid2 in yeast | Reider et al., 2009 |
| AP180/CALM | Yap1801/2 | ANTH | Yes | SNAREs | Miller et al., 2011 |
| Epsin1/2/3 | Ent1/2 | ENTH | Yes | Notch ligands | Meloty-Kapella et al., 2012 |
| Eps15 | Ede1/End3 | – | – | – | – |
| Intersectin1/2 | Sla1/Pan1 | PH/C2 | Yes (for Sla1 in yeast) | Ste2 in yeast | Howard et al., 2002 |
| HIP1/HIP1R | Sla2 | ANTH | Yes | – | – |
| Dab2 | – | PTB | Yes | LDLR | Maurer and Cooper, 2006 |
| ARH | – | PTB | – | LDLR | Maurer and Cooper, 2006 |
| Numb | – | PTB | – | Notch | Santolini et al., 2000 |
| Stonin 2 | – | – | – | Synaptotagmin | Diril et al., 2006 |
| β-Arrestin 1/2 | – | Arginine/lysine residues | Yes | GPCRs | Ferguson et al., 1996 |
| Mammalian protein | Yeast homologue | Lipid-binding domain | Clathrin binding | Example of specific cargo uptake | Reference for cargo uptake |
| AP2 (α, β2, μ2, σ2) | AP2 (Apl3, Apl1, Apm4, Aps2) | α-Core domain and μ2 C-terminal domain | Yes | Transferrin receptor | Motley et al., 2003 |
| FCHo1/2 | Syp1 | F-BAR domain | – | Mid2 in yeast | Reider et al., 2009 |
| AP180/CALM | Yap1801/2 | ANTH | Yes | SNAREs | Miller et al., 2011 |
| Epsin1/2/3 | Ent1/2 | ENTH | Yes | Notch ligands | Meloty-Kapella et al., 2012 |
| Eps15 | Ede1/End3 | – | – | – | – |
| Intersectin1/2 | Sla1/Pan1 | PH/C2 | Yes (for Sla1 in yeast) | Ste2 in yeast | Howard et al., 2002 |
| HIP1/HIP1R | Sla2 | ANTH | Yes | – | – |
| Dab2 | – | PTB | Yes | LDLR | Maurer and Cooper, 2006 |
| ARH | – | PTB | – | LDLR | Maurer and Cooper, 2006 |
| Numb | – | PTB | – | Notch | Santolini et al., 2000 |
| Stonin 2 | – | – | – | Synaptotagmin | Diril et al., 2006 |
| β-Arrestin 1/2 | – | Arginine/lysine residues | Yes | GPCRs | Ferguson et al., 1996 |
ANTH, AP180 N-terminal homology; ENTH, epsin N-terminal homology; GPCR, G-protein–coupled receptor; LDLR, low-density lipoprotein receptor; PH, pleckstrin homology; PTB, phosphotyrosine binding. “–” indicates none known.