Embryonic lethality of ATM D2899A (G1 founder line) mice is not rescued by disruption of Nbs1, Ku80, or 53bp1
| Genotype | AtmTgD2899AAtm+/+ | Atm+/+ | AtmTgD2899AAtm+/− | Atm+/− | AtmTgD2899AAtm−/− | Atm−/− |
| Nbs1+/+ observed | 9 | 10 | 14 | 10 | 0 | 11 |
| Nbs1+/+ expected | 7 | 7 | 15 | 15 | 7 | 7 |
| Nbs1ΔB/+ observed | 16 | 20 | 42 | 38 | 0 | 16 |
| Nbs1ΔB/+ expected | 15 | 15 | 30 | 30 | 15 | 15 |
| Nbs1ΔB/ΔB observed | 7 | 12 | 14 | 19 | 0 | 0 |
| Nbs1ΔB/ΔB expected | 7 | 7 | 15 | 15 | 7 | 7 |
| Ku80+/+ observed | 16 | 9 | 21 | 16 | 0 | 2 |
| Ku80+/+ expected | 10 | 3 | 19 | 6 | 10 | 3 |
| Ku80+/− observed | 21 | 16 | 41 | 26 | 0 | 9 |
| Ku80+/− expected | 19 | 6 | 39 | 13 | 19 | 6 |
| Ku80−/− observed | 9 | 1 | 17 | 3 | 0 | 0 |
| Ku80−/− expected | 10 | 3 | 19 | 6 | 10 | 3 |
| 53bp1−/− observed | 14 | 11 | 52 | 19 | 0 | 6 |
| 53bp1−/− expected | 19 | 6 | 38 | 13 | 19 | 6 |
| Genotype | AtmTgD2899AAtm+/+ | Atm+/+ | AtmTgD2899AAtm+/− | Atm+/− | AtmTgD2899AAtm−/− | Atm−/− |
| Nbs1+/+ observed | 9 | 10 | 14 | 10 | 0 | 11 |
| Nbs1+/+ expected | 7 | 7 | 15 | 15 | 7 | 7 |
| Nbs1ΔB/+ observed | 16 | 20 | 42 | 38 | 0 | 16 |
| Nbs1ΔB/+ expected | 15 | 15 | 30 | 30 | 15 | 15 |
| Nbs1ΔB/ΔB observed | 7 | 12 | 14 | 19 | 0 | 0 |
| Nbs1ΔB/ΔB expected | 7 | 7 | 15 | 15 | 7 | 7 |
| Ku80+/+ observed | 16 | 9 | 21 | 16 | 0 | 2 |
| Ku80+/+ expected | 10 | 3 | 19 | 6 | 10 | 3 |
| Ku80+/− observed | 21 | 16 | 41 | 26 | 0 | 9 |
| Ku80+/− expected | 19 | 6 | 39 | 13 | 19 | 6 |
| Ku80−/− observed | 9 | 1 | 17 | 3 | 0 | 0 |
| Ku80−/− expected | 10 | 3 | 19 | 6 | 10 | 3 |
| 53bp1−/− observed | 14 | 11 | 52 | 19 | 0 | 6 |
| 53bp1−/− expected | 19 | 6 | 38 | 13 | 19 | 6 |
Shown are the expected and observed genotypes of 3-wk-old pups from breeding Nbs1ΔB/+AtmTgD2899AAtm+/− with Nbs1ΔB/+Atm+/− mice (n = 238), intercrossing Ku80+/−AtmTgD2899AAtm+/− mice (n = 207), or intercrossing 53bp1−/−AtmTgD2899AAtm+/− mice (n = 102). Note the numbers of ATM kinase-inactive live-born pups in the different Ku80 backgrounds, the comparison between the number of ATM kinase-inactive and Atm-null live-born pups in the 53bp1-/- background, and the numbers of ATM kinase-inactive live-born pups in the different Nbs1 backgrounds.