Table 1.

Partial embryonic lethality in SnoNm/m embryos

Stage SnoNm/m SnoN+/m SnoN+/+ 
Postnatal 43 127 100 15.9: 47.0: 37.1 
E16.5–E18.5 10 31 20 16.4: 50.8: 32.8 
E12.5 22 10 15.8: 57.9: 26.3 
E10.5–E11.5 15 28 17 25.0: 46.7: 28.3 
Stage SnoNm/m SnoN+/m SnoN+/+ 
Postnatal 43 127 100 15.9: 47.0: 37.1 
E16.5–E18.5 10 31 20 16.4: 50.8: 32.8 
E12.5 22 10 15.8: 57.9: 26.3 
E10.5–E11.5 15 28 17 25.0: 46.7: 28.3 

Partial lethality of the SnoNm/m embryos occurs between E11.5 and E12.5. Offspring resulting from heterozygous intercrosses were genotyped at various embryonic developmental stages. Significant deviation from the Mendelian ratio is detected after E11.5.

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