Table 3.

Chromosome analysis of lymphoma/leukemia derived from K243R/+ mice

Genotype Tissue/tumor Age (n) Metaphase counted Diploid (2N = 40) Aneuploid (loss/gain) PMSCS 
  wk  % % % 
BubR1+/+a Spleen 60 (3) 65 95.5 4.5 (2.25/2.25) 
BubR1K243R/+a Spleen 60 (6) 319 48 52 (42/10) 
BubR1K243R/+ Lymphoma 57 98 46 54 (33/19) 31 
BubR1K243R/+ Lymphoma/leukemia 1 65 76 62 38 (22/16) 14 
BubR1K243R/+ Lymphoma/leukemia 2 104 137 51 49 (30/19) 19 
Genotype Tissue/tumor Age (n) Metaphase counted Diploid (2N = 40) Aneuploid (loss/gain) PMSCS 
  wk  % % % 
BubR1+/+a Spleen 60 (3) 65 95.5 4.5 (2.25/2.25) 
BubR1K243R/+a Spleen 60 (6) 319 48 52 (42/10) 
BubR1K243R/+ Lymphoma 57 98 46 54 (33/19) 31 
BubR1K243R/+ Lymphoma/leukemia 1 65 76 62 38 (22/16) 14 
BubR1K243R/+ Lymphoma/leukemia 2 104 137 51 49 (30/19) 19 
a

Normal splenocytes from adult mice of the indicated genotypes and ages. Splenocytes were activated using 10 µg/ml lipopolysaccharides, and a chromosome spread was performed.

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