Table 1.

Quantification of neuron positioning defects in SDF1a-TP– and SDF1a-ctrl-TP–injected embryos

Genotype Embryos with mispositioned neurons Total embryos Total mispositioned neurons Severity Penetrance 
     % 
Wild-type; SDF1a-ctrl-TP 12 166 36 0.22 7.23 
Mean   0.18   
SD   0.9   
SEM   0.06   
Wild-type; SDF1a-TP 41 84 242 2.88 48.81 
Mean   2.88   
SD   4.83   
SEM   0.53   
Wild-type; SDF1a-TP; SDF1a-AUG 28 74 198 2.68 37.84 
Mean   2.68   
SD   4.72   
SEM   0.55   
cxcr7b−/+; SDF1a-ctrl-TP 11 85 36 0.42 12.94 
Mean   0.42   
SD   1.23   
SEM   0.13   
cxcr7b−/+; SDF1a-TP 130 193 1143 5.92 67.36 
Mean   5.92   
SD   5.5   
SEM   0.4   
cxcr7b−/+; SDF1a-TP; SDF1a-AUG 71 112 400 3.57 63.39 
Mean   3.57   
SD   4.05   
SEM   0.38   
cxcr7b−/−; SDF1a-ctrl-TP 31 31 506 16.32 100 
Mean   16.32   
SD   7.05   
SEM   1.27   
cxcr7b−/−; SDF1a-TP 21 21 496 23.62 100 
Mean   22.25   
SD   6.35   
SEM   1.35   
Genotype Embryos with mispositioned neurons Total embryos Total mispositioned neurons Severity Penetrance 
     % 
Wild-type; SDF1a-ctrl-TP 12 166 36 0.22 7.23 
Mean   0.18   
SD   0.9   
SEM   0.06   
Wild-type; SDF1a-TP 41 84 242 2.88 48.81 
Mean   2.88   
SD   4.83   
SEM   0.53   
Wild-type; SDF1a-TP; SDF1a-AUG 28 74 198 2.68 37.84 
Mean   2.68   
SD   4.72   
SEM   0.55   
cxcr7b−/+; SDF1a-ctrl-TP 11 85 36 0.42 12.94 
Mean   0.42   
SD   1.23   
SEM   0.13   
cxcr7b−/+; SDF1a-TP 130 193 1143 5.92 67.36 
Mean   5.92   
SD   5.5   
SEM   0.4   
cxcr7b−/+; SDF1a-TP; SDF1a-AUG 71 112 400 3.57 63.39 
Mean   3.57   
SD   4.05   
SEM   0.38   
cxcr7b−/−; SDF1a-ctrl-TP 31 31 506 16.32 100 
Mean   16.32   
SD   7.05   
SEM   1.27   
cxcr7b−/−; SDF1a-TP 21 21 496 23.62 100 
Mean   22.25   
SD   6.35   
SEM   1.35   

Mispositioned neurons were defined as neurons anterior or adjacent to the MHB at the 10-somite stage. Severity is defined as the average number of mispositioned neurons per embryo. Penetrance is defined as the frequency of embryos with mispositioned neurons.

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