Table 1. Quantification of neuron... | Rockefeller University Press

Table 1.

Quantification of neuron positioning defects in SDF1a-TP– and SDF1a-ctrl-TP–injected embryos

Genotype	Embryos with mispositioned neurons	Total embryos	Total mispositioned neurons	Severity	Penetrance
					%
*Wild-type; SDF1a-ctrl-TP*	12	166	36	0.22	7.23
Mean			0.18
SD			0.9
SEM			0.06
*Wild-type; SDF1a-TP*	41	84	242	2.88	48.81
Mean			2.88
SD			4.83
SEM			0.53
*Wild-type; SDF1a-TP; SDF1a-AUG*	28	74	198	2.68	37.84
Mean			2.68
SD			4.72
SEM			0.55
cxcr7b^−/+; SDF1a-ctrl-TP	11	85	36	0.42	12.94
Mean			0.42
SD			1.23
SEM			0.13
cxcr7b^−/+; SDF1a-TP	130	193	1143	5.92	67.36
Mean			5.92
SD			5.5
SEM			0.4
cxcr7b^−/+; SDF1a-TP; SDF1a-AUG	71	112	400	3.57	63.39
Mean			3.57
SD			4.05
SEM			0.38
cxcr7b^−/−; SDF1a-ctrl-TP	31	31	506	16.32	100
Mean			16.32
SD			7.05
SEM			1.27
cxcr7b^−/−; SDF1a-TP	21	21	496	23.62	100
Mean			22.25
SD			6.35
SEM			1.35

Genotype	Embryos with mispositioned neurons	Total embryos	Total mispositioned neurons	Severity	Penetrance
					%
Wild-type; SDF1a-ctrl-TP	12	166	36	0.22	7.23
Mean			0.18
SD			0.9
SEM			0.06
Wild-type; SDF1a-TP	41	84	242	2.88	48.81
Mean			2.88
SD			4.83
SEM			0.53
Wild-type; SDF1a-TP; SDF1a-AUG	28	74	198	2.68	37.84
Mean			2.68
SD			4.72
SEM			0.55
cxcr7b^−/+; SDF1a-ctrl-TP	11	85	36	0.42	12.94
Mean			0.42
SD			1.23
SEM			0.13
cxcr7b^−/+; SDF1a-TP	130	193	1143	5.92	67.36
Mean			5.92
SD			5.5
SEM			0.4
cxcr7b^−/+; SDF1a-TP; SDF1a-AUG	71	112	400	3.57	63.39
Mean			3.57
SD			4.05
SEM			0.38
cxcr7b^−/−; SDF1a-ctrl-TP	31	31	506	16.32	100
Mean			16.32
SD			7.05
SEM			1.27
cxcr7b^−/−; SDF1a-TP	21	21	496	23.62	100
Mean			22.25
SD			6.35
SEM			1.35

Mispositioned neurons were defined as neurons anterior or adjacent to the MHB at the 10-somite stage. Severity is defined as the average number of mispositioned neurons per embryo. Penetrance is defined as the frequency of embryos with mispositioned neurons.

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