Table 2.

Plasmids used and constructed in this study

Plasmid Relevant features Source 
pBAD24 Cloning vector for expression of genes under control of the araBAD promoter Guzman et al., 1995  
pTM123-MBP pBAD24 producing aa 1–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
pTM12KK3-MBP pTM123-MBP with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pKK123-MBP pTM123-MBP with substitution of aa 54 of Sco2149 from R to K This study 
p130-MBP pBAD24, producing aa 130–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p148-MBP pBAD24, producing aa 148–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p154-MBP pBAD24, producing aa 154–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p158-MBP pBAD24, producing aa 158–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p158KK-MBP pBAD24, 158-MBP with exchange of aa 161–162 RR into KK This study 
pMltA(2TM)-130-MBP pBAD24 producing a fusion protein comprising aa 1–86 of E. coli MltA, aa 130–185 of Sco2149 and aa 27–396 of E. coli MBP This study 
pMltA(2TM)-TM123-MBP pBAD24 producing a fusion protein comprising aa 1–86 of E. coli MltA, aa 1–185 of Sco2149 and aa 27–396 of E. coli MBP This study 
pSU18 CmR Bartolomé et al., 1991  
pSUAmiA pSU18, amiA+ Ize et al., 2003  
pTM123-AmiA pBAD24 producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pSU-TM123-AmiA pSU18 producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pTM12KK3-AmiA pTM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pSU-TM12KK3-AmiA pSU-TM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
psU-TM123-(AxA)AmiA pSU18 producing aa 1–185 of Sco2149 fused to aa 32–289 of E. coli AmiA This study 
pET22b+ AmpRT7 promoter preceding multiple cloning site EMD Millipore 
pET-TM123-AmiA pET22b, producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pET-TM12KK3-AmiA pET-TM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pET302 pTRC99A-derived vector containing lacZR behind the trc promoter, a His tag and an enterokinase site van der Does et al., 1998  
pET2302 pET302 containing secYEG behind trc promoter with N-terminally His-tagged SecY de Keyzer et al., 2002  
pTRC99A AmpR lac promoter preceding multiple cloning site Amann et al., 1988  
pTRC99AYidC pTRC99A carrying yidC Saller et al., 2009  
pQE60 Cloning vector for producing histidine tagged proteins QIAGEN 
pQESco2149 pQE60 producing Sco2149 with a C-terminal hexa-histidine tag This study 
Plasmid Relevant features Source 
pBAD24 Cloning vector for expression of genes under control of the araBAD promoter Guzman et al., 1995  
pTM123-MBP pBAD24 producing aa 1–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
pTM12KK3-MBP pTM123-MBP with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pKK123-MBP pTM123-MBP with substitution of aa 54 of Sco2149 from R to K This study 
p130-MBP pBAD24, producing aa 130–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p148-MBP pBAD24, producing aa 148–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p154-MBP pBAD24, producing aa 154–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p158-MBP pBAD24, producing aa 158–185 of Sco2149 fused to aa 27–396 of E. coli MBP This study 
p158KK-MBP pBAD24, 158-MBP with exchange of aa 161–162 RR into KK This study 
pMltA(2TM)-130-MBP pBAD24 producing a fusion protein comprising aa 1–86 of E. coli MltA, aa 130–185 of Sco2149 and aa 27–396 of E. coli MBP This study 
pMltA(2TM)-TM123-MBP pBAD24 producing a fusion protein comprising aa 1–86 of E. coli MltA, aa 1–185 of Sco2149 and aa 27–396 of E. coli MBP This study 
pSU18 CmR Bartolomé et al., 1991  
pSUAmiA pSU18, amiA+ Ize et al., 2003  
pTM123-AmiA pBAD24 producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pSU-TM123-AmiA pSU18 producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pTM12KK3-AmiA pTM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pSU-TM12KK3-AmiA pSU-TM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
psU-TM123-(AxA)AmiA pSU18 producing aa 1–185 of Sco2149 fused to aa 32–289 of E. coli AmiA This study 
pET22b+ AmpRT7 promoter preceding multiple cloning site EMD Millipore 
pET-TM123-AmiA pET22b, producing aa 1–185 of Sco2149 fused to aa 33–289 of E. coli AmiA This study 
pET-TM12KK3-AmiA pET-TM123-AmiA with substitution of aa 161–162 of Sco2149 from RR to KK This study 
pET302 pTRC99A-derived vector containing lacZR behind the trc promoter, a His tag and an enterokinase site van der Does et al., 1998  
pET2302 pET302 containing secYEG behind trc promoter with N-terminally His-tagged SecY de Keyzer et al., 2002  
pTRC99A AmpR lac promoter preceding multiple cloning site Amann et al., 1988  
pTRC99AYidC pTRC99A carrying yidC Saller et al., 2009  
pQE60 Cloning vector for producing histidine tagged proteins QIAGEN 
pQESco2149 pQE60 producing Sco2149 with a C-terminal hexa-histidine tag This study 

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