Table 2. Correlating changes in the... | Rockefeller University Press

Table 2.

Correlating changes in the parameters k_f, k_a, and n with outputs in the ADPr⁻ and ADPr⁺ models

k_f^(min−1)	k_a(m³⁽ⁿ⁻¹⁾−mole⁻⁽ⁿ⁻¹⁾−min⁻¹)	n	Aggregation		Degradation
			ADPr⁻	ADPr⁺	ADPr⁻	ADPr⁺
			mol/24 h		mol/24 h
0.2	5	3	136.6	107.7	314.6	300.7
2	5	3	16.4	14.8	108.0	80.2
20	5	3	1.1	1.1	13.2	9.0
2	38.2	4	16.4	14.0	108.0	80.2
2	290	5	16.3	13.3	108.0	80.3

k_f^(min−1)	k_a(m³⁽ⁿ⁻¹⁾−mole⁻⁽ⁿ⁻¹⁾−min⁻¹)	n	Aggregation		Degradation
			ADPr⁻	ADPr⁺	ADPr⁻	ADPr⁺
			mol/24 h		mol/24 h
0.2	5	3	136.6	107.7	314.6	300.7
2	5	3	16.4	14.8	108.0	80.2
20	5	3	1.1	1.1	13.2	9.0
2	38.2	4	16.4	14.0	108.0	80.2
2	290	5	16.3	13.3	108.0	80.3

The effects of changing the rate of folding (k_f) or the terms governing the concentration dependence of aggregation (k_a and n) on rates of aggregation and degradation integrated over a 24-h cycle after the ER had reached a periodic steady state in the two models are shown.

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