Table 2.

Summary of the parameters used in this study

Variable Description Value Range 
N Number of chromosomes 
Mk Number of ktMTs per kinetochore 
tA Anaphase transition time 720 s 600–900 s 
δt Time step 1 s 0.1–3 
L0 Spindle initial length 0.3 µm 0.1–5 µm 
dc Centromere pair rest length 0.05 µm 0.01–0.2 µm 
κc Cohesion spring constant 90 pN/µm 10–200 pN/µm 
κk Spring constant of the bond between attachment site and the centromere 40 pN/µm 10–200 pN/µm 
μk Damping coefficient for the attachment site 900 pN.s/µm 100–2,000 pN.s/µm 
μc Sister chromatid friction coefficient 400 pN.s/µm 100–2,000 pN.s/µm 
μs SPB friction coefficient 500 pN.s/µm 100–2,000 pN.s/µm 
Fk ktMT motor stall force 10 pN Fixed 
Vk ktMT motor maximum velocity 0.03 µm/s 0.01–0.06 µm/s 
Fmz Midzone motor stall force 127 pN 50–500 pN 
Vmz Midzone motor maximum velocity 0.03 µm/s 0.01–0.06 µm/s 
ka Attachment rate 0.06/s 0.01–0.1 /s 
dα Aurora B–like activity coefficient 0.2 µm 0.01–1 µm 
β Kinetochore orientation effect coefficient 0–1 
Variable Description Value Range 
N Number of chromosomes 
Mk Number of ktMTs per kinetochore 
tA Anaphase transition time 720 s 600–900 s 
δt Time step 1 s 0.1–3 
L0 Spindle initial length 0.3 µm 0.1–5 µm 
dc Centromere pair rest length 0.05 µm 0.01–0.2 µm 
κc Cohesion spring constant 90 pN/µm 10–200 pN/µm 
κk Spring constant of the bond between attachment site and the centromere 40 pN/µm 10–200 pN/µm 
μk Damping coefficient for the attachment site 900 pN.s/µm 100–2,000 pN.s/µm 
μc Sister chromatid friction coefficient 400 pN.s/µm 100–2,000 pN.s/µm 
μs SPB friction coefficient 500 pN.s/µm 100–2,000 pN.s/µm 
Fk ktMT motor stall force 10 pN Fixed 
Vk ktMT motor maximum velocity 0.03 µm/s 0.01–0.06 µm/s 
Fmz Midzone motor stall force 127 pN 50–500 pN 
Vmz Midzone motor maximum velocity 0.03 µm/s 0.01–0.06 µm/s 
ka Attachment rate 0.06/s 0.01–0.1 /s 
dα Aurora B–like activity coefficient 0.2 µm 0.01–1 µm 
β Kinetochore orientation effect coefficient 0–1 

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