Table 1. Human GPCRs with conserved YPX... | Rockefeller University Press

Table 1.

Human GPCRs with conserved YPX_nL motifs

Family	IUPHAR nomenclature	NCBI Protein database accession no.	YPX_nL location	Sequence
Adrenoceptors	α_1B Adrenoceptor	P35368	ICL2	141-DRYIGRYSLQYPTLVT-158
Angiotensin	AT₂	P50052	ICL2	140-DRYQSVIYPFLSQRRN-157
Galanin	GAL₂	O43603	ICL2	121-DRYLAIRYPLHSRELRT-139
Histamine	H₂	P25021	ICL2	114-DRYCAVMDPLRYPVLVT-132
Neuropeptide FF	NPFF2	A0PJM9	ICL2	141-DRFQCVVYPFKPKLTIK-159
Neuropeptide S	NPS receptor	Q6W5P4	ICL2	144-DRYHAIVYPMKFLQGE-161
Protease activated	PAR1	P25116	ICL2	198-DRFLAVVYPMQSLSWRT-216
P2Y	P2Y₁	P47900	ICL2	147-HRYSGVVYPLKSLGRLK-165
Melanocortin	MC₄	P32245	Cytoplasmic tail	318-YPLGGLCDLSSRY-stop

Family	IUPHAR nomenclature	NCBI Protein database accession no.	YPX_nL location	Sequence
Adrenoceptors	α_1B Adrenoceptor	P35368	ICL2	141-DRYIGRYSLQYPTLVT-158
Angiotensin	AT₂	P50052	ICL2	140-DRYQSVIYPFLSQRRN-157
Galanin	GAL₂	O43603	ICL2	121-DRYLAIRYPLHSRELRT-139
Histamine	H₂	P25021	ICL2	114-DRYCAVMDPLRYPVLVT-132
Neuropeptide FF	NPFF2	A0PJM9	ICL2	141-DRFQCVVYPFKPKLTIK-159
Neuropeptide S	NPS receptor	Q6W5P4	ICL2	144-DRYHAIVYPMKFLQGE-161
Protease activated	PAR1	P25116	ICL2	198-DRFLAVVYPMQSLSWRT-216
P2Y	P2Y₁	P47900	ICL2	147-HRYSGVVYPLKSLGRLK-165
Melanocortin	MC₄	P32245	Cytoplasmic tail	318-YPLGGLCDLSSRY-stop

A search of 397 class A GPCR cytoplasmic sequences for YPX_nL motifs was completed by sequence alignment using the GPCR database (Vroling et al., 2011). Of these, several GPCRs contained sequences conforming to the YPX_nL motif in the ICL2 (bold) and were aligned starting with the DRY/F motif. The list includes the GPCR family name, International Union of Basic and Clinical Pharmacology (IUPHAR) nomenclature, and NCBI accession numbers.

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