Mutant p53-regulated events that impact cell migration
| “Direct” target genes | Via p63 inhibition | Secondary machinery | Downstream consequences | References | |
| Cellular level | Tissue level | ||||
| RhoGEF-H1 ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Mizuarai et al., 2006 |
| RhoGDI ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| IGF1R ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| Paxillin-β ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| WISP2/CCN5 ↓ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Dhar et al., 2008 |
| Sharp-1 ↓ | Yes | NA | Unknown | Tumor cell migration and invasion ↑ | Adorno et al., 2009 |
| Cyclin G2 ↓ | Yes | NA | Unknown | Tumor cell migration and invasion ↑ | Adorno et al., 2009 |
| Unknown | Yes | RCP-dependent trafficking | α5β1 integrin/EGFR recycling | Tumor cell migration and invasion ↑ | Muller et al., 2009 |
| Twist ↑ | Unknown | NA | Unknown | EMT | Kogan-Sakin et al., 2010 |
| “Direct” target genes | Via p63 inhibition | Secondary machinery | Downstream consequences | References | |
| Cellular level | Tissue level | ||||
| RhoGEF-H1 ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Mizuarai et al., 2006 |
| RhoGDI ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| IGF1R ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| Paxillin-β ↑ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Bossi et al., 2008 |
| WISP2/CCN5 ↓ | Unknown | NA | Integrin and Rho GTPase signalling ↑ | Cell growth and migration ↑ | Dhar et al., 2008 |
| Sharp-1 ↓ | Yes | NA | Unknown | Tumor cell migration and invasion ↑ | Adorno et al., 2009 |
| Cyclin G2 ↓ | Yes | NA | Unknown | Tumor cell migration and invasion ↑ | Adorno et al., 2009 |
| Unknown | Yes | RCP-dependent trafficking | α5β1 integrin/EGFR recycling | Tumor cell migration and invasion ↑ | Muller et al., 2009 |
| Twist ↑ | Unknown | NA | Unknown | EMT | Kogan-Sakin et al., 2010 |
Selected list of genes/proteins that affect EMT, cell migration, invasion, and metastasis that are regulated by mutant p53 in a gain-of-function manner. p53 status, expression of mutant p53s in p53−/− background.