Loss of p53 function in cell migration
| Primary transcriptional targets | Posttranscriptional effects | Secondary transcriptional targets | Downstream consequences | References | |
| Cellular level | Tissue level | ||||
| Unknown | Slug ↑ (due to reduced mdm2-mediated degradation) | E-Cadherin ↓ | Cell–cell junctions ↓ | EMT-like phenotype | Cano et al., 1996; Shiota et al., 2008; Wang et al., 2009b |
| EpCAM ↑ | Unknown | NA | Cell–cell junctions ↓ | EMT-like phenotype | Sankpal et al., 2009 |
| RhoE ↓ | ROCK ↑ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Ongusaha et al., 2006; Riento and Ridley, 2006 |
| RhoE ↓ | p190RhoGAP ↓ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Wennerberg et al., 2003 |
| RhoE ↓ | Syx RhoGEF ↑ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Goh and Manser, 2010 |
| ROCK ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Guo and Zheng, 2004; Gadea et al., 2007; Lefort et al., 2007; Qin et al., 2009 |
| Notch ↓ | NA | MRCKα↑, ROCK↑ | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Lefort et al., 2007 |
| Fibronectin ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Guo and Zheng, 2004 |
| Collagens ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Zhao et al., 2000 |
| LASP1 ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Wang et al., 2009a |
| PTEN ↓ | Various | Rac/ Cdc42↑ | Rac and PKB/Akt signalling ↑ | Cell migration (2D and 3D) ↑ | Stambolic et al., 2001; Guo et al., 2003; Guo and Zheng, 2004; Gadea et al., 2007 |
| MMP2 ↑ | NA | NA | NA | ECM degradation ↑ | Delassus et al., 2010 |
| miRNA-143 ↑ | Various | NA | Invadopodia ↑ | ECM degradation ↑ | Quintavalle et al., 2010 |
| Caldesmon ↑ | NA | NA | Invadopodia ↑ | ECM degradation ↑ | Mukhopadhyay et al., 2009 |
| Primary transcriptional targets | Posttranscriptional effects | Secondary transcriptional targets | Downstream consequences | References | |
| Cellular level | Tissue level | ||||
| Unknown | Slug ↑ (due to reduced mdm2-mediated degradation) | E-Cadherin ↓ | Cell–cell junctions ↓ | EMT-like phenotype | Cano et al., 1996; Shiota et al., 2008; Wang et al., 2009b |
| EpCAM ↑ | Unknown | NA | Cell–cell junctions ↓ | EMT-like phenotype | Sankpal et al., 2009 |
| RhoE ↓ | ROCK ↑ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Ongusaha et al., 2006; Riento and Ridley, 2006 |
| RhoE ↓ | p190RhoGAP ↓ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Wennerberg et al., 2003 |
| RhoE ↓ | Syx RhoGEF ↑ | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Goh and Manser, 2010 |
| ROCK ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Guo and Zheng, 2004; Gadea et al., 2007; Lefort et al., 2007; Qin et al., 2009 |
| Notch ↓ | NA | MRCKα↑, ROCK↑ | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Lefort et al., 2007 |
| Fibronectin ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Guo and Zheng, 2004 |
| Collagens ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Zhao et al., 2000 |
| LASP1 ↑ | NA | NA | Rho signaling ↑ | Cell migration (2D and 3D) ↑ | Wang et al., 2009a |
| PTEN ↓ | Various | Rac/ Cdc42↑ | Rac and PKB/Akt signalling ↑ | Cell migration (2D and 3D) ↑ | Stambolic et al., 2001; Guo et al., 2003; Guo and Zheng, 2004; Gadea et al., 2007 |
| MMP2 ↑ | NA | NA | NA | ECM degradation ↑ | Delassus et al., 2010 |
| miRNA-143 ↑ | Various | NA | Invadopodia ↑ | ECM degradation ↑ | Quintavalle et al., 2010 |
| Caldesmon ↑ | NA | NA | Invadopodia ↑ | ECM degradation ↑ | Mukhopadhyay et al., 2009 |
Selected list of genes with an involvement in EMT, cell migration, and ECM degradation that are regulated by p53. p53 status, suppression or loss of wild-type p53.