Table I. Relevant genetic mouse models... | Rockefeller University Press

Table I.

Relevant genetic mouse models that have contributed to the understanding of HSC cell cycle regulation

Category	Gene(s)	Genetic model	HSC cell cycle activity	Developmental stage	References
Cell-intrinsic mechanisms
Cell cycle regulators	pRb/p107/p130	Mx1-Cre conditional deletion	Increased	Adult	Viatour et al., 2008
	CyclinD1/D2/D3	Triple knockout	Decreased	Fetal	Kozar et al., 2004
	Cdk4/6	Double knockout	Decreased	Fetal	Malumbres et al., 2004
	p21^Cip1	Knockout	Decreased or unchanged	Adult	Cheng et al., 2000a; van Os et al., 2007; Foudi et al., 2009
	p57^Kip2	Mx1-Cre conditional deletion	Increased	Adult	Matsumoto et al., 2011
	p27^Kip1/p57^Kip2	Double knockout; fetal liver HSC transplant	Increased	Fetal, Adult	Zou et al., 2011
	p18^ink4c	Knockout	Increased	Adult	Yuan et al 2004
Transcription factors	p53	Knockout	Increased	Adult	Liu et al., 2009
	p53	Hypermorphic allele	Decreased	Old	Dumble et al., 2007
	junB	More-Cre conditional deletion	Increased	Adult	Santaguida et al., 2009
PI3K pathway	Pten	Mx1-Cre conditional deletion	Increased	Adult	Yilmaz et al., 2006; Zhang et al., 2006
	Tsc1	Knockout	Increased	Adult	C. Chen et al., 2008
	Akt1/2	Double knockout	Decreased	Adult	Juntilla et al., 2010
	myr-Akt	Retroviral expression	Increased	Adult	Kharas and Gritsman 2010
	Foxo1/3/4	Triple knockout	Increased	Adult	Tothova et al., 2007
	Foxo3	Knockout	Increased	Adult	Miyamoto et al., 2007
Cell-extrinsic mechanisms
Environmental factors	Tpo	Knockout	Increased	Fetal, Adult	Qian et al., 2007
	Ang-1	Retroviral expression	Decreased	Adult	Arai et al., 2004
	Kit	Hypomorphic allele	Increased	Fetal, Adult	Thorén et al., 2008
	Cxcr4	Rosa^Cre-Ert2 conditional deletion	Increased	Adult	Nie et al., 2008
Developmental pathways	Dkk	Col1α2.3-driven transgene	Increased	Adult	Fleming et al., 2008
	Gli1	Knockout	Decreased	Adult	Merchant et al., 2010

Category	Gene(s)	Genetic model	HSC cell cycle activity	Developmental stage	References
Cell-intrinsic mechanisms
Cell cycle regulators	pRb/p107/p130	Mx1-Cre conditional deletion	Increased	Adult	Viatour et al., 2008
	CyclinD1/D2/D3	Triple knockout	Decreased	Fetal	Kozar et al., 2004
	Cdk4/6	Double knockout	Decreased	Fetal	Malumbres et al., 2004
	p21^Cip1	Knockout	Decreased or unchanged	Adult	Cheng et al., 2000a; van Os et al., 2007; Foudi et al., 2009
	p57^Kip2	Mx1-Cre conditional deletion	Increased	Adult	Matsumoto et al., 2011
	p27^Kip1/p57^Kip2	Double knockout; fetal liver HSC transplant	Increased	Fetal, Adult	Zou et al., 2011
	p18^ink4c	Knockout	Increased	Adult	Yuan et al 2004
Transcription factors	p53	Knockout	Increased	Adult	Liu et al., 2009
	p53	Hypermorphic allele	Decreased	Old	Dumble et al., 2007
	junB	More-Cre conditional deletion	Increased	Adult	Santaguida et al., 2009
PI3K pathway	Pten	Mx1-Cre conditional deletion	Increased	Adult	Yilmaz et al., 2006; Zhang et al., 2006
	Tsc1	Knockout	Increased	Adult	C. Chen et al., 2008
	Akt1/2	Double knockout	Decreased	Adult	Juntilla et al., 2010
	myr-Akt	Retroviral expression	Increased	Adult	Kharas and Gritsman 2010
	Foxo1/3/4	Triple knockout	Increased	Adult	Tothova et al., 2007
	Foxo3	Knockout	Increased	Adult	Miyamoto et al., 2007
Cell-extrinsic mechanisms
Environmental factors	Tpo	Knockout	Increased	Fetal, Adult	Qian et al., 2007
	Ang-1	Retroviral expression	Decreased	Adult	Arai et al., 2004
	Kit	Hypomorphic allele	Increased	Fetal, Adult	Thorén et al., 2008
	Cxcr4	Rosa^Cre-Ert2 conditional deletion	Increased	Adult	Nie et al., 2008
Developmental pathways	Dkk	Col1α2.3-driven transgene	Increased	Adult	Fleming et al., 2008
	Gli1	Knockout	Decreased	Adult	Merchant et al., 2010

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