Table I. Diagram depicting the... | Rockefeller University Press

Table I.

Diagram depicting the structural domains and function of mTOR


Domain	Function	Reference
HEAT REPEAT^a	Protein–protein interaction; membrane localization	Andrade and Bork, 1995; Kunz et al., 2000; Perry and Kleckner, 2003
FAT^b	Protein–protein interaction; kinase domain folding or organization	Bosotti et al., 2000
FRB^c	Rapamycin sensitivity and substrate selectivity	Cafferkey et al., 1994; Chen et al., 1995; Mcmahon et al., 2002
KINASE^d	Ser–Thr protein kinase	Brunn et al., 1997; Burnett et al., 1998
NRD^e	Phosphorylated in response to insulin and growth factors	Scott et al., 1998; Navé et al.,1999; Sekulić et al., 2000
FATC^f	Kinase domain folding or organization	Alarcon et al., 1999; Bosotti et al., 2000; Takahashi et al., 2000


Domain	Function	Reference
HEAT REPEATa	Protein–protein interaction; membrane localization	Andrade and Bork, 1995; Kunz et al., 2000; Perry and Kleckner, 2003
FATb	Protein–protein interaction; kinase domain folding or organization	Bosotti et al., 2000
FRBc	Rapamycin sensitivity and substrate selectivity	Cafferkey et al., 1994; Chen et al., 1995; Mcmahon et al., 2002
KINASEd	Ser–Thr protein kinase	Brunn et al., 1997; Burnett et al., 1998
NRDe	Phosphorylated in response to insulin and growth factors	Scott et al., 1998; Navé et al.,1999; Sekulić et al., 2000
FATCf	Kinase domain folding or organization	Alarcon et al., 1999; Bosotti et al., 2000; Takahashi et al., 2000

Huntingtin, elongation factor 3, protein phosphatase 2A, yeast PI3-kinase TOR1.

FRAP (FKBP12-rapamycin-associated protein)/TOR, ATM (ataxia-telangiectasia), TRRAP (transactivation/tranformation domain-associated protein).

FKBP12-rapamycin binding.

Catalytic domain of PIKK.

Negative regulatory domain.

FRAP, ATM, TRRAP C-terminal.

Sharing Unavailable