Table I.
Diagram depicting the structural domains and function of mTOR
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| Domain | Function | Reference |
| HEAT REPEATa | Protein–protein interaction; membrane localization | Andrade and Bork, 1995; Kunz et al., 2000; Perry and Kleckner, 2003 |
| FATb | Protein–protein interaction; kinase domain folding or organization | Bosotti et al., 2000 |
| FRBc | Rapamycin sensitivity and substrate selectivity | Cafferkey et al., 1994; Chen et al., 1995; Mcmahon et al., 2002 |
| KINASEd | Ser–Thr protein kinase | Brunn et al., 1997; Burnett et al., 1998 |
| NRDe | Phosphorylated in response to insulin and growth factors | Scott et al., 1998; Navé et al.,1999; Sekulić et al., 2000 |
| FATCf | Kinase domain folding or organization | Alarcon et al., 1999; Bosotti et al., 2000; Takahashi et al., 2000 |
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| Domain | Function | Reference |
| HEAT REPEATa | Protein–protein interaction; membrane localization | Andrade and Bork, 1995; Kunz et al., 2000; Perry and Kleckner, 2003 |
| FATb | Protein–protein interaction; kinase domain folding or organization | Bosotti et al., 2000 |
| FRBc | Rapamycin sensitivity and substrate selectivity | Cafferkey et al., 1994; Chen et al., 1995; Mcmahon et al., 2002 |
| KINASEd | Ser–Thr protein kinase | Brunn et al., 1997; Burnett et al., 1998 |
| NRDe | Phosphorylated in response to insulin and growth factors | Scott et al., 1998; Navé et al.,1999; Sekulić et al., 2000 |
| FATCf | Kinase domain folding or organization | Alarcon et al., 1999; Bosotti et al., 2000; Takahashi et al., 2000 |
a
Huntingtin, elongation factor 3, protein phosphatase 2A, yeast PI3-kinase TOR1.
b
FRAP (FKBP12-rapamycin-associated protein)/TOR, ATM (ataxia-telangiectasia), TRRAP (transactivation/tranformation domain-associated protein).
c
FKBP12-rapamycin binding.
d
Catalytic domain of PIKK.
e
Negative regulatory domain.
f
FRAP, ATM, TRRAP C-terminal.