Table I. Characteristics of Arf6 mutant... | Rockefeller University Press

Table I.

Characteristics of Arf6 mutant proteins

Arf6 mutant protein	Phenotype	Citation	VSVG sorting^a
Arf6Q67L	Locked in GTP form	Donaldson, 2003	Apical
Arf6D125N	Binds xanthine nucleotides, presumed nucleotide-free in cells	Yang and Mueckler, 1999	Apical
Arf6T27N	Locked in GDP form	Macia et al., 2004	Basolateral
Arf6N48I	Deficient in PLD activation	Vitale et al., 2005; Jovanovic et al., 2006	Basolateral
Arf6Q67L/Q37E/S38I	Defective in actin remodeling	Al-Awar et al., 2000; Palacios et al., 2001	Apical
Arf6G2A	Can no longer be myristoylated	Knorr et al., 2000	ND
Arf6D125N/G2A	Presumed nucleotide-free, not myristoylated	This paper	Apical
Arf6Q67L/G2A	Locked in GTP form, not myristoylated	This paper	Apical

Arf6 mutant protein	Phenotype	Citation	VSVG sortinga
Arf6Q67L	Locked in GTP form	Donaldson, 2003	Apical
Arf6D125N	Binds xanthine nucleotides, presumed nucleotide-free in cells	Yang and Mueckler, 1999	Apical
Arf6T27N	Locked in GDP form	Macia et al., 2004	Basolateral
Arf6N48I	Deficient in PLD activation	Vitale et al., 2005; Jovanovic et al., 2006	Basolateral
Arf6Q67L/Q37E/S38I	Defective in actin remodeling	Al-Awar et al., 2000; Palacios et al., 2001	Apical
Arf6G2A	Can no longer be myristoylated	Knorr et al., 2000	ND
Arf6D125N/G2A	Presumed nucleotide-free, not myristoylated	This paper	Apical
Arf6Q67L/G2A	Locked in GTP form, not myristoylated	This paper	Apical

The VSVG sorting phenotypes in the presence of Arf6 mutant proteins were all obtained in this study.