Increasing aneuploidy in lymphocytes from Bub1 transgenic mice
| Mouse genotype | Age (n) | Mitotic figures inspected | Aneuploid figures (SD) | Karyotypes with indicated chromosome number | Mitotic figures with PMSCS (SD) | |||||||
| 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | |||||
| % | % | |||||||||||
| WT | 1 d (3) | 150 | 1 (1) | 1 | 148 | 1 | 1 (1) | |||||
| WT | 6 wk (3) | 150 | 2 (2) | 2 | 147 | 1 | 1 (2) | |||||
| WT | 5 mo (3) | 150 | 4 (0) | 1 | 2 | 144 | 3 | 1 (1) | ||||
| Bub1T85 | 1 d (3) | 150 | 21 (3) | 3 | 3 | 5 | 14 | 119 | 5 | 1 | 3 (1) | |
| Bub1T85 | 6 wk (3) | 150 | 31 (2) | 1 | 8 | 17 | 104 | 13 | 4 | 3 | 3 (1) | |
| Bub1T85 | 5 mo (3) | 150 | 35 (6) | 4 | 4 | 11 | 23 | 97 | 8 | 3 | 1 (2) | |
| Bub1T264 | 1 d (3) | 150 | 15 (2) | 2 | 1 | 4 | 8 | 127 | 7 | 1 | 0 (0) | |
| Bub1T264 | 6 wk (3) | 150 | 30 (3) | 4 | 1 | 6 | 15 | 105 | 14 | 5 | 3 (1) | |
| Bub1T264 | 5 mo (3) | 150 | 28 (2) | 2 | 1 | 8 | 16 | 108 | 12 | 3 | 6 (3) | |
| Mouse genotype | Age (n) | Mitotic figures inspected | Aneuploid figures (SD) | Karyotypes with indicated chromosome number | Mitotic figures with PMSCS (SD) | |||||||
| 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | |||||
| % | % | |||||||||||
| WT | 1 d (3) | 150 | 1 (1) | 1 | 148 | 1 | 1 (1) | |||||
| WT | 6 wk (3) | 150 | 2 (2) | 2 | 147 | 1 | 1 (2) | |||||
| WT | 5 mo (3) | 150 | 4 (0) | 1 | 2 | 144 | 3 | 1 (1) | ||||
| Bub1T85 | 1 d (3) | 150 | 21 (3) | 3 | 3 | 5 | 14 | 119 | 5 | 1 | 3 (1) | |
| Bub1T85 | 6 wk (3) | 150 | 31 (2) | 1 | 8 | 17 | 104 | 13 | 4 | 3 | 3 (1) | |
| Bub1T85 | 5 mo (3) | 150 | 35 (6) | 4 | 4 | 11 | 23 | 97 | 8 | 3 | 1 (2) | |
| Bub1T264 | 1 d (3) | 150 | 15 (2) | 2 | 1 | 4 | 8 | 127 | 7 | 1 | 0 (0) | |
| Bub1T264 | 6 wk (3) | 150 | 30 (3) | 4 | 1 | 6 | 15 | 105 | 14 | 5 | 3 (1) | |
| Bub1T264 | 5 mo (3) | 150 | 28 (2) | 2 | 1 | 8 | 16 | 108 | 12 | 3 | 6 (3) | |
Empty spaces mean that there were no karyotypes with the indicated chromosome number.