A survey of disease states associated with defects in engulfment-related genes
| Gene | Disease relationship | Human/mouse | References |
| Find me | |||
| G2A | AI | M | Le et al., 2001 |
| CX3CR1 | Neuropathy | M | Cardona et al., 2006 |
| CX3CL1 | Atherosclerosis | M | Combadière et al., 2003 |
| Eat-me/tickling | |||
| MER | AI, cancer, neuropathy, atherosclerosis | H/M | Gal et al., 2000; Scott et al., 2001; Cohen et al., 2002; Keating et al., 2006; Nandrot et al., 2007; Ait-Oufella et al., 2008; Thorp et al., 2008 |
| MFG-E8 | AI, atherosclerosis, neuropathy | M | Hanayama et al., 2004; Ait-Oufella et al., 2007; Nandrot et al., 2007 |
| C1q | AI, atherosclerosis, neuropathy | M | Botto et al., 1998; Fonseca et al., 2004; Bhatia et al., 2007 |
| αvβ3/5 | AI, atherosclerosis | M | Weng et al., 2003; Lacy-Hulbert et al., 2007 |
| TIM-4 | AI | M | Rodriguez-Manzanet et al., 2010 |
| Gas6 | Atherosclerosis | M | Lutgens et al., 2008 |
| Engulfment | |||
| ELMO1 | Diabetic nephropathya | H | Shimazaki et al., 2005; Leak et al., 2009; Pezzolesi et al., 2009a |
| GULP1 | Arthritisa, schizophreniaa | H | Qingchun et al., 2008; Chen et al., 2009 |
| MEGF10 | Schizophreniaa | H | Chen et al., 2009 |
| Post-engulfment | |||
| LXRα/β | AI | M | A-Gonzalez et al., 2009 |
| PPARδ | AI | M | Mukundan et al., 2009 |
| DNase II | AI | M | Kawane et al., 2003 |
| Gene | Disease relationship | Human/mouse | References |
| Find me | |||
| G2A | AI | M | Le et al., 2001 |
| CX3CR1 | Neuropathy | M | Cardona et al., 2006 |
| CX3CL1 | Atherosclerosis | M | Combadière et al., 2003 |
| Eat-me/tickling | |||
| MER | AI, cancer, neuropathy, atherosclerosis | H/M | Gal et al., 2000; Scott et al., 2001; Cohen et al., 2002; Keating et al., 2006; Nandrot et al., 2007; Ait-Oufella et al., 2008; Thorp et al., 2008 |
| MFG-E8 | AI, atherosclerosis, neuropathy | M | Hanayama et al., 2004; Ait-Oufella et al., 2007; Nandrot et al., 2007 |
| C1q | AI, atherosclerosis, neuropathy | M | Botto et al., 1998; Fonseca et al., 2004; Bhatia et al., 2007 |
| αvβ3/5 | AI, atherosclerosis | M | Weng et al., 2003; Lacy-Hulbert et al., 2007 |
| TIM-4 | AI | M | Rodriguez-Manzanet et al., 2010 |
| Gas6 | Atherosclerosis | M | Lutgens et al., 2008 |
| Engulfment | |||
| ELMO1 | Diabetic nephropathya | H | Shimazaki et al., 2005; Leak et al., 2009; Pezzolesi et al., 2009a |
| GULP1 | Arthritisa, schizophreniaa | H | Qingchun et al., 2008; Chen et al., 2009 |
| MEGF10 | Schizophreniaa | H | Chen et al., 2009 |
| Post-engulfment | |||
| LXRα/β | AI | M | A-Gonzalez et al., 2009 |
| PPARδ | AI | M | Mukundan et al., 2009 |
| DNase II | AI | M | Kawane et al., 2003 |
Genes are grouped by known roles in engulfment (find-me, eat-me, engulfment, and post-engulfment). AI, autoimmune phenotype; H, human; M, mouse.
There is evidence of genetic linkage but no direct causal relationship was established.