Table I.

Phenotypes induced by the expression of N-terminal AKAP450 fragments

AKAP450 fragments Golgi integrity Golgi positioning Secretion CTR/GA reorientation Directional migration Primary cilium formation 
AKAP4501–3,899 aa +++ +++ +++ +++ +++ +++ 
AK1 domain1–1,029 aa ++ − ++ +/− − − 
AK1B domain159–463 aa − +++ ++ ++ − 
AKAP450 fragments Golgi integrity Golgi positioning Secretion CTR/GA reorientation Directional migration Primary cilium formation 
AKAP4501–3,899 aa +++ +++ +++ +++ +++ +++ 
AK1 domain1–1,029 aa ++ − ++ +/− − − 
AK1B domain159–463 aa − +++ ++ ++ − 

+++, normal phenotype; ++, slightly affected; +, mildly affected; +/−, moderately affected; −, strongly affected.

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