Table I. RBM4 and PTB differentially... | Rockefeller University Press

Table I.

RBM4 and PTB differentially modulate alternative splicing of a set of muscle-specific transcripts

Transcript	AS exon¹	Muscle isoform	CU-rich motifs
			Exon	Intron
RBM4 and PTB show the same effect; both promote the expression of muscle-specific isoforms.
PTB	e11	Skip	+	+
nPTB	e10	Skip	+	+
MEF2c	α1/α2	Include α2	+ (α2)	+ (α2)
MEF2c	β	Skip	−	+
RBM4 and PTB show the opposite effect; RBM4 promotes the expression of muscle-specific isoforms
RBM4 skips; PTB includes
Palladin	e4	Skip	−	+
fTnT	E6 and 7	Skip	+²	+
α-Actinin³	e19	Skip	+	+
RBM4 includes; PTB skips
α-Tropomyosin	e9a	Include (sk⁴)	−	+
cTnT	e5	Include	−	+
IR	e11	Include	−	+
Ryr	e83	Include	−	+
Myocardin	e11	Include	+	−
Vinculin³	e19	Include	−	+

Transcript	AS exon¹	Muscle isoform	CU-rich motifs
			Exon	Intron
RBM4 and PTB show the same effect; both promote the expression of muscle-specific isoforms.
PTB	e11	Skip	+	+
nPTB	e10	Skip	+	+
MEF2c	α1/α2	Include α2	+ (α2)	+ (α2)
MEF2c	β	Skip	−	+
RBM4 and PTB show the opposite effect; RBM4 promotes the expression of muscle-specific isoforms
RBM4 skips; PTB includes
Palladin	e4	Skip	−	+
fTnT	E6 and 7	Skip	+²	+
α-Actinin³	e19	Skip	+	+
RBM4 includes; PTB skips
α-Tropomyosin	e9a	Include (sk⁴)	−	+
cTnT	e5	Include	−	+
IR	e11	Include	−	+
Ryr	e83	Include	−	+
Myocardin	e11	Include	+	−
Vinculin³	e19	Include	−	+

¹AS exon, alternatively spliced exon.

²The CU-rich sequence is located between exons 6 and 7, but is not present in the exons.

³Data for the RT-PCR analysis are not shown in Fig. 6.

⁴sk, skeletal muscle cell.