Associations between genes up-regulated in intermediate erythroblasts
| DNA-FISH . | Numbers of nuclei scored for associations between genes . | Fisher's exact test p-value . | |
|---|---|---|---|
. | Erythroblast . | Lymphoblast . | . |
| HBA-HBA | 800 | 2,200 | 4.91 × 10−25 |
| ERAF-ERAF | 1,100 | 1,500 | 2.64 × 10−09 |
| SLC4A1-SLC4A1 | 600 | 1,600 | 1.79 × 10−37 |
| HBB-HBB | 1,900 | 1,300 | 0.0011 |
| GATA1-GATA1 | 1,100 | 1,200 | 0.056 |
| HBA-SLC4A1 | 400 | 300 | 5.47 × 10−17 |
| HBA-ERAF | 400 | 400 | 0.0015 |
| HBA-HBB | 700 | 400 | 5.52 × 10−11 |
| HBA-GATA1 | 200 | 400 | 3.62 × 10−06 |
| SLC4A1-ERAF | 500 | 500 | 9.96 × 10−10 |
| SLC4A1-HBB | 400 | 400 | 4.79 × 10−05 |
| HBB-ERAF | 400 | 400 | 0.00042 |
| DNA-FISH . | Numbers of nuclei scored for associations between genes . | Fisher's exact test p-value . | |
|---|---|---|---|
. | Erythroblast . | Lymphoblast . | . |
| HBA-HBA | 800 | 2,200 | 4.91 × 10−25 |
| ERAF-ERAF | 1,100 | 1,500 | 2.64 × 10−09 |
| SLC4A1-SLC4A1 | 600 | 1,600 | 1.79 × 10−37 |
| HBB-HBB | 1,900 | 1,300 | 0.0011 |
| GATA1-GATA1 | 1,100 | 1,200 | 0.056 |
| HBA-SLC4A1 | 400 | 300 | 5.47 × 10−17 |
| HBA-ERAF | 400 | 400 | 0.0015 |
| HBA-HBB | 700 | 400 | 5.52 × 10−11 |
| HBA-GATA1 | 200 | 400 | 3.62 × 10−06 |
| SLC4A1-ERAF | 500 | 500 | 9.96 × 10−10 |
| SLC4A1-HBB | 400 | 400 | 4.79 × 10−05 |
| HBB-ERAF | 400 | 400 | 0.00042 |
P-values for Fisher's exact test of differences between associations scored in erythroblasts and lymphoblasts (Fig. 1). A p-value of 0.004 is required to achieve significance after a Bonferroni correction for multiplicity.