Biochemically-demonstrated interactions with CGH-1 orthologues
| Protein type . | C. elegans (adult hermaphroditeo) . | D. melanogaster (adult ovary) . | X. laevis (oocytes) . | S. cerevisiae . | H. sapiens (HeLa cells) . |
|---|---|---|---|---|---|
| DEAD box RNA helicase | CGH-1 | Me31B | Xp54 | Dhh1p | RCK |
| Sm-like domain | CAR-1bc | Tralbg | RAP55hi | ? | ? |
| CPEB family | ? | ? | CPEBhi | − | ? |
| Y-box | CEY-2, 3, 4b | Ypsdefg | FRGY2hi | − | ? |
| KH domain | ATX-2a | ? | ? | ? | ataxin-2l |
| Poly A–binding | PAB-1a | Pabpg | PABPh | Pbp1pj | ? |
| eIF4E | ? | eIF4Efg | ? | ? | eIF4Em |
| eIF4E-binding | ? | Cupfg | eIF4E-Th | ? | ? |
| Decapping enzymes | ? | ? | ? | Dcp1pj Dcp2pj | hDcp1m hDcp2mn |
| Enhancer of decapping/ translational repressor | PATR-1a | ? | P100h | Pat1pj | ? |
| Enhancer of decapping | ? | ? | ? | Edc3pj | Edc3n |
| Decapping factors | ? | ? | ? | Lsm1-7pjk | ? |
| Protein type . | C. elegans (adult hermaphroditeo) . | D. melanogaster (adult ovary) . | X. laevis (oocytes) . | S. cerevisiae . | H. sapiens (HeLa cells) . |
|---|---|---|---|---|---|
| DEAD box RNA helicase | CGH-1 | Me31B | Xp54 | Dhh1p | RCK |
| Sm-like domain | CAR-1bc | Tralbg | RAP55hi | ? | ? |
| CPEB family | ? | ? | CPEBhi | − | ? |
| Y-box | CEY-2, 3, 4b | Ypsdefg | FRGY2hi | − | ? |
| KH domain | ATX-2a | ? | ? | ? | ataxin-2l |
| Poly A–binding | PAB-1a | Pabpg | PABPh | Pbp1pj | ? |
| eIF4E | ? | eIF4Efg | ? | ? | eIF4Em |
| eIF4E-binding | ? | Cupfg | eIF4E-Th | ? | ? |
| Decapping enzymes | ? | ? | ? | Dcp1pj Dcp2pj | hDcp1m hDcp2mn |
| Enhancer of decapping/ translational repressor | PATR-1a | ? | P100h | Pat1pj | ? |
| Enhancer of decapping | ? | ? | ? | Edc3pj | Edc3n |
| Decapping factors | ? | ? | ? | Lsm1-7pjk | ? |
The proteins shown have each been demonstrated to interact physically with CGH-1 orthologues. Interactions that have been identified only by yeast two-hybrid are not included. Some proteins that colocalize to P bodies, such as the CAR-1 orthologues Scd6 (yeast) and RAP55 (human), are also not included, as they have not been biochemically identified to interact with the corresponding CGH-1 orthologue. CPEB, cytoplasmic polyadenylation element–binding protein; ?, unambiguous orthologue exists, but no information is available. −, no clear orthologue described.
This paper.
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Protein extracts were prepared from whole adult hermaphrodites in which sperm production had ceased and oocytes were being produced.