List of NE proteins demonstrated to be degraded by autophagy or the UPS
| NE protein . | Species . | Degradation mechanism . | E3 ligase . | Reference . |
|---|---|---|---|---|
| Mps3 | Saccharomyces cerevisiae | UPS | Anaphase-promoting complex | Koch et al. (2019) |
| Heh2 | Saccharomyces cerevisiae | UPS | Asi1 | Smoyer et al. (2019) |
| Per33 | Saccharomyces cerevisiae | UPS | Asi1 | Smoyer et al. (2019) |
| Asi2 | Saccharomyces cerevisiae | UPS | Asi1, Doa10 | Smoyer et al. (2019); Pantazopoulou et al. (2016) |
| Asi1 | Saccharomyces cerevisiae | UPS | Unknown | Pantazopoulou et al. (2016) |
| Nup85 | Saccharomyces cerevisiae | UPS | Unknown | Webster et al. (2014) |
| Heh1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mochida et al. (2015) |
| Hmg1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mochida et al. (2015) |
| Nur1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mostofa et al. (2018) |
| Whole NPCs | Saccharomyces cerevisiae | Nucleophagy | NA | Tomioka et al. (2020); Lee et al. (2020) |
| Nurim | Mouse | UPS | Unknown | Buchwalter et al. (2019) |
| Nup62 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup153 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup214 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup358 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Lamin B | Mouse, zebrafish | UPS | Wdr26 | Zhen et al. (2020) |
| β-Dystroglycan | Mouse | UPS | Unknown | Vélez-Aguilera et al. (2018) |
| Emerin | Mouse, human | UPS (mouse and human), nucleophagy (human) | Unknown | Buchwalter et al. (2019); Muchir et al. (2006); Lenain et al. (2015) |
| SUN1 | Arabidopsis, human | UPS (Arabidopsis), nucleophagy (human) | Unknown | Huang et al. (2020); Lenain et al. (2015) |
| SUN2 | Human | UPS | Skp1βTRCP1/2 | Coyaud et al. (2015); Kim et al. (2015) |
| LBR | Human | UPS, nucleophagy | Unknown | Tsai et al. (2016); Lenain et al. (2015) |
| Nup188 | Human | UPS | Unknown | Vishnoi et al. (2020) |
| LAP2α | Human | UPS | RNF123 | Khanna et al. (2018) |
| Lamin B1 | Human | UPS, nucleophagy | RNF123 | Dou et al. (2015); Khanna et al. (2018); Lenain et al. (2015) |
| NE protein . | Species . | Degradation mechanism . | E3 ligase . | Reference . |
|---|---|---|---|---|
| Mps3 | Saccharomyces cerevisiae | UPS | Anaphase-promoting complex | Koch et al. (2019) |
| Heh2 | Saccharomyces cerevisiae | UPS | Asi1 | Smoyer et al. (2019) |
| Per33 | Saccharomyces cerevisiae | UPS | Asi1 | Smoyer et al. (2019) |
| Asi2 | Saccharomyces cerevisiae | UPS | Asi1, Doa10 | Smoyer et al. (2019); Pantazopoulou et al. (2016) |
| Asi1 | Saccharomyces cerevisiae | UPS | Unknown | Pantazopoulou et al. (2016) |
| Nup85 | Saccharomyces cerevisiae | UPS | Unknown | Webster et al. (2014) |
| Heh1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mochida et al. (2015) |
| Hmg1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mochida et al. (2015) |
| Nur1 | Saccharomyces cerevisiae | Nucleophagy | NA | Mostofa et al. (2018) |
| Whole NPCs | Saccharomyces cerevisiae | Nucleophagy | NA | Tomioka et al. (2020); Lee et al. (2020) |
| Nurim | Mouse | UPS | Unknown | Buchwalter et al. (2019) |
| Nup62 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup153 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup214 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Nup358 | Mouse | UPS | Unknown | Zhu et al. (2016) |
| Lamin B | Mouse, zebrafish | UPS | Wdr26 | Zhen et al. (2020) |
| β-Dystroglycan | Mouse | UPS | Unknown | Vélez-Aguilera et al. (2018) |
| Emerin | Mouse, human | UPS (mouse and human), nucleophagy (human) | Unknown | Buchwalter et al. (2019); Muchir et al. (2006); Lenain et al. (2015) |
| SUN1 | Arabidopsis, human | UPS (Arabidopsis), nucleophagy (human) | Unknown | Huang et al. (2020); Lenain et al. (2015) |
| SUN2 | Human | UPS | Skp1βTRCP1/2 | Coyaud et al. (2015); Kim et al. (2015) |
| LBR | Human | UPS, nucleophagy | Unknown | Tsai et al. (2016); Lenain et al. (2015) |
| Nup188 | Human | UPS | Unknown | Vishnoi et al. (2020) |
| LAP2α | Human | UPS | RNF123 | Khanna et al. (2018) |
| Lamin B1 | Human | UPS, nucleophagy | RNF123 | Dou et al. (2015); Khanna et al. (2018); Lenain et al. (2015) |
NA, not applicable.