Table 4. sBCMA-Fc V3 single-dose... | Rockefeller University Press

Table 4.

sBCMA-Fc V3 single-dose toxicology study design

Group	Number of animals		Animal number		Treatment	Dose level (mg/kg)	Concentration (mg/ml)	Dose volume (ml/kg)
Group	Male	Female	Male	Female	Treatment	Dose level (mg/kg)	Concentration (mg/ml)	Dose volume (ml/kg)
1	1	1	1,101	2,102	Vehicle	0	0	10
2	1	1	1,203	2,204	sBCMA-Fc V3	0.1	0.01	10
3	1	1	1,305	2,306	sBCMA-Fc V3	1	0.1	10
4	1	1	1,407	2,408	sBCMA-Fc V3	10	1	10
5	1	1	1,509	2,510	sBCMA-Fc V3	100	10	10

Group	Number of animals		Animal number		Treatment	Dose level (mg/kg)	Concentration (mg/ml)	Dose volume (ml/kg)
Group	Male	Female	Male	Female	Treatment	Dose level (mg/kg)	Concentration (mg/ml)	Dose volume (ml/kg)
1	1	1	1,101	2,102	Vehicle	0	0	10
2	1	1	1,203	2,204	sBCMA-Fc V3	0.1	0.01	10
3	1	1	1,305	2,306	sBCMA-Fc V3	1	0.1	10
4	1	1	1,407	2,408	sBCMA-Fc V3	10	1	10
5	1	1	1,509	2,510	sBCMA-Fc V3	100	10	10

Body weight recording: predose days −14, −6; after-dose days 1, 2, 7, 14, 21, 28, 35, and 42. Blood sample collection: predose days −13, −16, 1; after-dose days 2, 7, 14, and 42.

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