Parameters for [Ca2+]cyt-dependent Ca2+ release activities of CPVT and artificial mutants
| Parameter . | Amax . | KACa (mM) . | KICa (mM) . |
|---|---|---|---|
| Mock | 0 | ||
| WT | 0.1248 | 1.62 × 10–2 | 3.002 |
| V2321M | 0.1847 | 1.10 × 10–2 | 4.847 |
| R2474S | 0.2175 | 7.03 × 10–3 | 11.31 |
| D3638A | 0.1214 | 1.10 × 10–2 | 2.058 |
| Q4201R | 0.1473 | 1.04 × 10–2 | 4.454 |
| K4392R | 0.1324 | 1.80 × 10–2 | 2.759 |
| R4497C | 0.1779 | 1.29 × 10–2 | 5.553 |
| K4751Q | 0.2733 | 7.65 × 10–3 | 1,000 |
| H4762P | 0.09848 | 2.94 × 10–3 | 19.5 |
| K4805R | 0.2857 | 7.35 × 10–3 | 159.5 |
| I4867M | 0.08865 | 8.96 × 10–3 | 1.832 |
| T4754A | 0.1245 | 2.03 × 10–2 | 2.178 |
| I4755A | 0.06616 | 8.18 × 10–3 | 1.829 |
| L4756A | 0.1925 | 2.22 × 10–3 | 741.6 |
| S4757A | 0.1684 | 1.38 × 10–2 | 6.967 |
| S4758A | 0.05471 | 1.95 × 10–2 | 3.245 |
| T4754I | 0.2953 | 8.40 × 10–3 | 17.13 |
| Parameter . | Amax . | KACa (mM) . | KICa (mM) . |
|---|---|---|---|
| Mock | 0 | ||
| WT | 0.1248 | 1.62 × 10–2 | 3.002 |
| V2321M | 0.1847 | 1.10 × 10–2 | 4.847 |
| R2474S | 0.2175 | 7.03 × 10–3 | 11.31 |
| D3638A | 0.1214 | 1.10 × 10–2 | 2.058 |
| Q4201R | 0.1473 | 1.04 × 10–2 | 4.454 |
| K4392R | 0.1324 | 1.80 × 10–2 | 2.759 |
| R4497C | 0.1779 | 1.29 × 10–2 | 5.553 |
| K4751Q | 0.2733 | 7.65 × 10–3 | 1,000 |
| H4762P | 0.09848 | 2.94 × 10–3 | 19.5 |
| K4805R | 0.2857 | 7.35 × 10–3 | 159.5 |
| I4867M | 0.08865 | 8.96 × 10–3 | 1.832 |
| T4754A | 0.1245 | 2.03 × 10–2 | 2.178 |
| I4755A | 0.06616 | 8.18 × 10–3 | 1.829 |
| L4756A | 0.1925 | 2.22 × 10–3 | 741.6 |
| S4757A | 0.1684 | 1.38 × 10–2 | 6.967 |
| S4758A | 0.05471 | 1.95 × 10–2 | 3.245 |
| T4754I | 0.2953 | 8.40 × 10–3 | 17.13 |