Table 1.

Macroscopic parameters of mice

ParameterSham
(n = 12)
HF
(n = 12)
Body parameters 
Lung weight/tibia length
Heart weight/tibia length 
9.52 ± 0.87
9.80 ± 0.66 
15.41 ± 5.26a
16.78 ± 3.64a 
Echocardiographic data 
FS (%) 27.62 ± 3.46 13.62 ± 3.15a 
EF (%) 60.38 ± 5.61 33.94 ± 7.03a 
IVSd (mm) 0.64 ± 0.10 0.65 ± 0.10 
IVSs (mm) 0.92 ± 0.10 0.81 ± 0.14a 
LVIDd (mm) 3.76 ± 0.38 4.44 ± 0.52a 
LVIDs (mm) 2.73 ± 0.35 3.83 ± 0.48a 
LVPWd (mm) 0.68 ± 0.14 0.78 ± 0.28 
LVPWs (mm) 0.84 ± 0.10 0.86 ± 0.28 
LV mass (mg) 81.60 ± 20.68 124.95 ± 65.78a 
HR (beats/min) 470 ± 34.64 486 ± 38.10 
ParameterSham
(n = 12)
HF
(n = 12)
Body parameters 
Lung weight/tibia length
Heart weight/tibia length 
9.52 ± 0.87
9.80 ± 0.66 
15.41 ± 5.26a
16.78 ± 3.64a 
Echocardiographic data 
FS (%) 27.62 ± 3.46 13.62 ± 3.15a 
EF (%) 60.38 ± 5.61 33.94 ± 7.03a 
IVSd (mm) 0.64 ± 0.10 0.65 ± 0.10 
IVSs (mm) 0.92 ± 0.10 0.81 ± 0.14a 
LVIDd (mm) 3.76 ± 0.38 4.44 ± 0.52a 
LVIDs (mm) 2.73 ± 0.35 3.83 ± 0.48a 
LVPWd (mm) 0.68 ± 0.14 0.78 ± 0.28 
LVPWs (mm) 0.84 ± 0.10 0.86 ± 0.28 
LV mass (mg) 81.60 ± 20.68 124.95 ± 65.78a 
HR (beats/min) 470 ± 34.64 486 ± 38.10 

FS, fractionnal shortening; EF, ejection fraction; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVPWd, left ventricular posterior wall thickness at end-diastole; LVPWs, left ventricular posterior wall thickness at end-systole. One-way ANOVA followed by Bonferroni test were used. All the values are mean ± SD.

a

P < 0.05 versus sham group.

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