Estimate of maximum rate of SR Ca2+ pumping in intact fast-twitch human muscle fibers
| Variable | Value |
|---|---|
| Isometric ATP turnovera | 2,333 μM s−1 |
| Fraction of ATP turnover by Ca pumpb | 0.35 |
| ATP turnover for Ca pumping at 37°C | 817 μM s−1 |
| ATP turnover for Ca pumping at 25°Cc | 355 μM s−1 |
| Maximum rate of Ca uptake at 25°Cd | 711 μM s−1 |
| Variable | Value |
|---|---|
| Isometric ATP turnover | 2,333 μM s−1 |
| Fraction of ATP turnover by Ca pump | 0.35 |
| ATP turnover for Ca pumping at 37°C | 817 μM s−1 |
| ATP turnover for Ca pumping at 25°C | 355 μM s−1 |
| Maximum rate of Ca uptake at 25°C | 711 μM s−1 |
Expressed relative to myoplasmic H2O volume; converted from 140 mM min−1 in sustained maximal contraction at 37°C (for details, see Barclay, 2017).
From data for type 2A human fibers (Szentesi et al., 2001) and other mammalian muscles (Barclay et al., 2007).
Assumed Q10 = 2 (Barclay, 2012).
Two Ca2+ translocated for each ATP-splitting cycle (Weber et al., 1966).
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