Subcellular localization of zinc transporters
| Zinc transporter . | Localization . | Detection Method . | Reference . | ||
|---|---|---|---|---|---|
| Immunofluorescence . | Cell fractionation and immunoblotting . | Zn2+ influx/efflux assay/measurement of [Zn2+] . | |||
| ZIP1 | PM | ✓ | ✓ | Gaither and Eide, 2001 | |
| Mitochondria | ✓ | ✓ | Cho et al., 2019 | ||
| ZIP2 | PM | ✓ | ✓ | Gaither and Eide, 2000 | |
| ZIP3 | PM | ✓ | Kelleher and Lönnerdal, 2003 | ||
| ZIP6 | PM | ✓ | Taylor and Nicholson, 2003 | ||
| ZIP7 | TGN | ✓ | ✓ | Huang et al., 2005 | |
| S/ER | ✓ | ✓ | ✓ | Tuncay et al., 2017 | |
| Mitochondria | ✓ | ✓ | ✓ | Tuncay et al., 2019 | |
| ZIP8 | PM | ✓ | ✓ | Dalton et al., 2005 | |
| Lysosomes | ✓ | Aydemir et al., 2009 | |||
| Mitochondria S/ER | ✓ ✓ | Olgar et al., 2019 | |||
| ZIP9 | PM | ✓ | ✓ | ✓ | Thomas et al., 2014 |
| TGN | ✓ | Matsuura et al., 2009 | |||
| ZIP10 | PM | ✓ | ✓ | Lichten et al., 2011 | |
| ZIP11 | TGN | ✓ | Kelleher et al., 2012 | ||
| Nucleus | ✓ | ✓ | Martin et al., 2013 | ||
| ZIP13 | TGN | ✓ | ✓ | Fukada et al., 2008 | |
| ZIP14 | PM | ✓ | Taylor et al., 2003 | ||
| S/ER | ✓ | Olgar et al., 2018a | |||
| ZnT1 | PM | ✓ | Palmiter and Findley, 1995 | ||
| ZnT2 | Lysosomes | ✓ | Palmiter et al., 1996 | ||
| ZnT5 | TGN | ✓ | ✓ | ✓ | Kambe et al., 2002 |
| ZnT6 | TGN | ✓ | ✓ | Suzuki et al., 2005 | |
| ZnT7 | TGN | ✓ | Kirschke and Huang, 2003 | ||
| S/ER | ✓ | ✓ | Tuncay et al., 2017 | ||
| Mitochondria | ✓ | ✓ | Tuncay et al., 2019 | ||
| ZnT8 | Mitochondria S/ER | ✓ ✓ | Olgar et al., 2019 | ||
| ZnT9 | Nucleus | ✓ | ✓ | Sim and Chow, 1999 | |
| Mitochondria | ✓ | Kowalczyk et al., 2021 | |||
| Zinc transporter . | Localization . | Detection Method . | Reference . | ||
|---|---|---|---|---|---|
| Immunofluorescence . | Cell fractionation and immunoblotting . | Zn2+ influx/efflux assay/measurement of [Zn2+] . | |||
| ZIP1 | PM | ✓ | ✓ | Gaither and Eide, 2001 | |
| Mitochondria | ✓ | ✓ | Cho et al., 2019 | ||
| ZIP2 | PM | ✓ | ✓ | Gaither and Eide, 2000 | |
| ZIP3 | PM | ✓ | Kelleher and Lönnerdal, 2003 | ||
| ZIP6 | PM | ✓ | Taylor and Nicholson, 2003 | ||
| ZIP7 | TGN | ✓ | ✓ | Huang et al., 2005 | |
| S/ER | ✓ | ✓ | ✓ | Tuncay et al., 2017 | |
| Mitochondria | ✓ | ✓ | ✓ | Tuncay et al., 2019 | |
| ZIP8 | PM | ✓ | ✓ | Dalton et al., 2005 | |
| Lysosomes | ✓ | Aydemir et al., 2009 | |||
| Mitochondria S/ER | ✓ ✓ | Olgar et al., 2019 | |||
| ZIP9 | PM | ✓ | ✓ | ✓ | Thomas et al., 2014 |
| TGN | ✓ | Matsuura et al., 2009 | |||
| ZIP10 | PM | ✓ | ✓ | Lichten et al., 2011 | |
| ZIP11 | TGN | ✓ | Kelleher et al., 2012 | ||
| Nucleus | ✓ | ✓ | Martin et al., 2013 | ||
| ZIP13 | TGN | ✓ | ✓ | Fukada et al., 2008 | |
| ZIP14 | PM | ✓ | Taylor et al., 2003 | ||
| S/ER | ✓ | Olgar et al., 2018a | |||
| ZnT1 | PM | ✓ | Palmiter and Findley, 1995 | ||
| ZnT2 | Lysosomes | ✓ | Palmiter et al., 1996 | ||
| ZnT5 | TGN | ✓ | ✓ | ✓ | Kambe et al., 2002 |
| ZnT6 | TGN | ✓ | ✓ | Suzuki et al., 2005 | |
| ZnT7 | TGN | ✓ | Kirschke and Huang, 2003 | ||
| S/ER | ✓ | ✓ | Tuncay et al., 2017 | ||
| Mitochondria | ✓ | ✓ | Tuncay et al., 2019 | ||
| ZnT8 | Mitochondria S/ER | ✓ ✓ | Olgar et al., 2019 | ||
| ZnT9 | Nucleus | ✓ | ✓ | Sim and Chow, 1999 | |
| Mitochondria | ✓ | Kowalczyk et al., 2021 | |||
Subcellular localization of ZIPs and ZnTs as illustrated in Fig. 1 A. PM, plasma membrane; TGN, trans-Golgi network.