Values for the fraction of baseline and shifted INa on the lateral and junctional membranes for the seven Na+ channel distributions investigated in tissue simulations, shown for a representative example of fNa = 0.7
| Distribution . | Baseline INa on lateral membrane . | Shifted INa on lateral membrane . | Baseline INa on junctional membranes . | Shifted INa on junctional membranes . |
|---|---|---|---|---|
| (1) Baseline/Lateral | 1 | 0 | 0 | 0 |
| (2) Shifted/Lateral | 0 | 1 | 0 | 0 |
| (3) Mix/Lateral | 0.3 (1 − fNa) | 0.7 (fNa) | 0 | 0 |
| (4) Baseline/Polarized | 0.3 (1 − fNa) | 0 | 0.7 (fNa) | 0 |
| (5) Shifted/Polarized | 0 | 0.3 (1 − fNa) | 0 | 0.7 (fNa) |
| (6) Mix/Het-polarized | 0.09 (1 − fNa)2 | 0.21 [fNa (1 − fNa)] | 0.21 [fNa (1 − fNa)] | 0.49 (fNa)2 |
| (7) Mix/Hom-polarized | 0.3 (1 − fNa) | 0 | 0 | 0.7 (fNa) |
| Distribution . | Baseline INa on lateral membrane . | Shifted INa on lateral membrane . | Baseline INa on junctional membranes . | Shifted INa on junctional membranes . |
|---|---|---|---|---|
| (1) Baseline/Lateral | 1 | 0 | 0 | 0 |
| (2) Shifted/Lateral | 0 | 1 | 0 | 0 |
| (3) Mix/Lateral | 0.3 (1 − fNa) | 0.7 (fNa) | 0 | 0 |
| (4) Baseline/Polarized | 0.3 (1 − fNa) | 0 | 0.7 (fNa) | 0 |
| (5) Shifted/Polarized | 0 | 0.3 (1 − fNa) | 0 | 0.7 (fNa) |
| (6) Mix/Het-polarized | 0.09 (1 − fNa)2 | 0.21 [fNa (1 − fNa)] | 0.21 [fNa (1 − fNa)] | 0.49 (fNa)2 |
| (7) Mix/Hom-polarized | 0.3 (1 − fNa) | 0 | 0 | 0.7 (fNa) |