Signaling molecules scaffolded by IQGAP1
| Interactor . | Binding site on IQGAP1 . | Effect of IQGAP1 binding . | Reference . |
|---|---|---|---|
| AMPK | |||
| CaMKK2 | IQ | Promotes AMPK activation | Hedman et al., 2021 |
| AMPK | IQ | ||
| Hippo | |||
| MST2 | IQ | Impairs MST2 and LATS1 kinase activity | Quinn et al., 2021 |
| LATS1 | IQ | ||
| YAP | IQ | Inhibits YAP cotranscriptional activity | Sayedyahossein et al., 2016 |
| Insulin | |||
| IR | IQ | Stimulates insulin signaling | Chawla et al., 2017 |
| IRS-1 | RGCT and distal C-terminus | ||
| JAK-STAT | |||
| STAT1 | n.d. | Activates the transcription factors STAT1/3 | Chen et al., 2022 |
| STAT3 | n.d. | ||
| MAPK | |||
| B-Raf | IQ | Facilitates the MAPK phosphorylation cascade, ultimately activating ERK1/2 | Ren et al., 2007 |
| C-Raf | IQ and RGCT | Sbroggiò et al., 2011 | |
| MEK1 | IQ | Roy et al., 2005 | |
| MEK2 | |||
| ERK1 | WW | ||
| ERK2 | Roy et al., 2004 | ||
| PI3K/Akt | |||
| PI4KIIIα | n.d. | Facilitates the formation of PIP3 | Choi et al., 2016; Tekletsadik et al., 2012 |
| PIPKIα | IQ | ||
| PI3K | WW and IQ | ||
| mTorC1 | N-terminal | Promotes Akt activation | |
| PDK1 | n.d. | ||
| Akt | IQ | ||
| Wnt | |||
| APC | RGCT | Scaffolds the degradation (APC) and activation (Dvl, PP2A) complexes of β-catenin | Watanabe et al., 2004 |
| Dvl | aa 901–1060 | Goto et al., 2013 | |
| PP2A | n.d. | Nakajima et al., 2005 | |
| β-catenin | RGCT | Kuroda et al., 1998 | |
| Small GTPases | |||
| Arf1 | IQ | Stimulates ERK activation | Hu et al., 2021 |
| Arf6 | n.d. | Stimulates Arf6-induced Rac1 activation | Hu et al., 2009 |
| Cdc42 | GRD | Stabilizes GTP-bound Cdc42 | Kuroda et al., 1996 |
| Rab27a | GRD | Regulates endocytosis | Kimura et al., 2013 |
| Rac1 | GRD | Stabilizes GTP-bound Rac1 | Kuroda et al., 1996 |
| Rac2 | n.d. | Unknown | Meng et al., 2007 |
| Ran1 | n.d. | Regulates β-catenin transcriptional function | Goto et al., 2013 |
| Rap1 | IQ | Reduces Rap1 activation | Jeong et al., 2007 |
| RhoA | n.d. | Modulates RhoA activation | Casteel et al., 2012 |
| RhoC | C-terminal | Stimulates RhoC activation | Wu et al., 2011 |
| RhoQ | n.d. | Unknown | Neudauer et al., 1998 |
| Interactor . | Binding site on IQGAP1 . | Effect of IQGAP1 binding . | Reference . |
|---|---|---|---|
| AMPK | |||
| CaMKK2 | IQ | Promotes AMPK activation | Hedman et al., 2021 |
| AMPK | IQ | ||
| Hippo | |||
| MST2 | IQ | Impairs MST2 and LATS1 kinase activity | Quinn et al., 2021 |
| LATS1 | IQ | ||
| YAP | IQ | Inhibits YAP cotranscriptional activity | Sayedyahossein et al., 2016 |
| Insulin | |||
| IR | IQ | Stimulates insulin signaling | Chawla et al., 2017 |
| IRS-1 | RGCT and distal C-terminus | ||
| JAK-STAT | |||
| STAT1 | n.d. | Activates the transcription factors STAT1/3 | Chen et al., 2022 |
| STAT3 | n.d. | ||
| MAPK | |||
| B-Raf | IQ | Facilitates the MAPK phosphorylation cascade, ultimately activating ERK1/2 | Ren et al., 2007 |
| C-Raf | IQ and RGCT | Sbroggiò et al., 2011 | |
| MEK1 | IQ | Roy et al., 2005 | |
| MEK2 | |||
| ERK1 | WW | ||
| ERK2 | Roy et al., 2004 | ||
| PI3K/Akt | |||
| PI4KIIIα | n.d. | Facilitates the formation of PIP3 | Choi et al., 2016; Tekletsadik et al., 2012 |
| PIPKIα | IQ | ||
| PI3K | WW and IQ | ||
| mTorC1 | N-terminal | Promotes Akt activation | |
| PDK1 | n.d. | ||
| Akt | IQ | ||
| Wnt | |||
| APC | RGCT | Scaffolds the degradation (APC) and activation (Dvl, PP2A) complexes of β-catenin | Watanabe et al., 2004 |
| Dvl | aa 901–1060 | Goto et al., 2013 | |
| PP2A | n.d. | Nakajima et al., 2005 | |
| β-catenin | RGCT | Kuroda et al., 1998 | |
| Small GTPases | |||
| Arf1 | IQ | Stimulates ERK activation | Hu et al., 2021 |
| Arf6 | n.d. | Stimulates Arf6-induced Rac1 activation | Hu et al., 2009 |
| Cdc42 | GRD | Stabilizes GTP-bound Cdc42 | Kuroda et al., 1996 |
| Rab27a | GRD | Regulates endocytosis | Kimura et al., 2013 |
| Rac1 | GRD | Stabilizes GTP-bound Rac1 | Kuroda et al., 1996 |
| Rac2 | n.d. | Unknown | Meng et al., 2007 |
| Ran1 | n.d. | Regulates β-catenin transcriptional function | Goto et al., 2013 |
| Rap1 | IQ | Reduces Rap1 activation | Jeong et al., 2007 |
| RhoA | n.d. | Modulates RhoA activation | Casteel et al., 2012 |
| RhoC | C-terminal | Stimulates RhoC activation | Wu et al., 2011 |
| RhoQ | n.d. | Unknown | Neudauer et al., 1998 |
Abbreviations: aa, amino acids; n.d., not determined.