n indicates number of biological replicates, i.e., number of mice
| . | Saline (n = 9) . | C3C10 (n = 8) . | FL (n = 13) . |
|---|---|---|---|
| Age (wk) | 6.32 ± 0.08 | 6.34 ± 0.05 | 6.25 ± 0.03 |
| HR (BPM) | 451 ± 2 | 448 ± 2 | 449 ± 2 |
| BW (g) | 17.44 ± 0.38 | 17.75 ± 0.59 | 16.31 ± 0.52 |
| LVM (mg) | 184.92 ± 5.93a, P < 0.000001 | 141.35 ± 6.05 aP < 0.000001, bP < 0.000001 | 105.57 ± 3.77, P < 0.000001 |
| LVM/BW (mg/g) | 10.61 ± 0.31a, P < 0.000001 | 7.97 ± 0.23 aP < 0.000001, bP < 0.000001 | 6.48 ± 0.10b, P < 0.000001 |
| LVAW:d (mm) | 1.19 ± 0.04a, P = 0.0046 | 1.065 ± 0.07 | 0.998 ± 0.03b, P = 0.0046 |
| LVPW:d (mm) | 1.35 ± 0.08a, P = 0.00010 | 1.12 ± 0.05b, P = 0.015 | 1.02 ± 0.03b, P = 0.00010 |
| Diameter:d (mm) | 4.05 ± 0.13a, P = 0.00024 | 3.93 ± 0.06a, P = 0.0056 | 3.50 ± 0.07b, P = 0.00024 |
| FS (%) | 15.97 ± 0.54a, P < 0.000001 | 21.15 ± 0.73b, P = 0.00006 | 22.91 ± 0.64b, P < 0.000001 |
| EF (%) | 34.02 ± 1.01a, P < 0.000001 | 43.51 ± 1.27b, P = 0.000033 | 46.9 ± 1.12b, P < 0.000001 |
| GLS (%) | −8.52 ± 0.65a, P < 0.000001 | −11.07 ± 0.26 aP = 0.019, bP = 0.0052 | −13.06 ± 0.43b, P < 0.000001 |
| AET (ms) | 32.18 ± 1.08a, P = 0.000023 | 35.00 ± 0.96a, P = 0.0014 | 41.62 ± 1.08b, P = 0.000023 |
| rLSR (s−1) | 3.51 ± 0.34a, P = 0.00070 | 4.32 ± 0.52a, P = 0.019 | 6.35 ± 0.52b, P = 0.00070 |
| . | Saline (n = 9) . | C3C10 (n = 8) . | FL (n = 13) . |
|---|---|---|---|
| Age (wk) | 6.32 ± 0.08 | 6.34 ± 0.05 | 6.25 ± 0.03 |
| HR (BPM) | 451 ± 2 | 448 ± 2 | 449 ± 2 |
| BW (g) | 17.44 ± 0.38 | 17.75 ± 0.59 | 16.31 ± 0.52 |
| LVM (mg) | 184.92 ± 5.93a, P < 0.000001 | 141.35 ± 6.05 aP < 0.000001, bP < 0.000001 | 105.57 ± 3.77, P < 0.000001 |
| LVM/BW (mg/g) | 10.61 ± 0.31a, P < 0.000001 | 7.97 ± 0.23 aP < 0.000001, bP < 0.000001 | 6.48 ± 0.10b, P < 0.000001 |
| LVAW:d (mm) | 1.19 ± 0.04a, P = 0.0046 | 1.065 ± 0.07 | 0.998 ± 0.03b, P = 0.0046 |
| LVPW:d (mm) | 1.35 ± 0.08a, P = 0.00010 | 1.12 ± 0.05b, P = 0.015 | 1.02 ± 0.03b, P = 0.00010 |
| Diameter:d (mm) | 4.05 ± 0.13a, P = 0.00024 | 3.93 ± 0.06a, P = 0.0056 | 3.50 ± 0.07b, P = 0.00024 |
| FS (%) | 15.97 ± 0.54a, P < 0.000001 | 21.15 ± 0.73b, P = 0.00006 | 22.91 ± 0.64b, P < 0.000001 |
| EF (%) | 34.02 ± 1.01a, P < 0.000001 | 43.51 ± 1.27b, P = 0.000033 | 46.9 ± 1.12b, P < 0.000001 |
| GLS (%) | −8.52 ± 0.65a, P < 0.000001 | −11.07 ± 0.26 aP = 0.019, bP = 0.0052 | −13.06 ± 0.43b, P < 0.000001 |
| AET (ms) | 32.18 ± 1.08a, P = 0.000023 | 35.00 ± 0.96a, P = 0.0014 | 41.62 ± 1.08b, P = 0.000023 |
| rLSR (s−1) | 3.51 ± 0.34a, P = 0.00070 | 4.32 ± 0.52a, P = 0.019 | 6.35 ± 0.52b, P = 0.00070 |
Values are expressed as mean ± SEM., analyzed by one-way ANOVA with post hoc Tukey’s multiple comparisons test. HR, heart rate; BW, body weight; LVM, left ventricle mass; LVAW:d, left ventricle anterior wall thickness in diastole; LVPW:d, left ventricle posterior wall thickness in diastole; Diameter:d, left ventricle diameter in diastole; FS, fractional shortening; EF, ejection fraction; GLS, global longitudinal strain; AET, aortic ejection time; rLSR, reverse longitudinal strain rate.
Significantly different compared to FL.
Significantly different compared to saline.