Table 1. Base model parameters Component... | Rockefeller University Press

Table 1.

Base model parameters

Component	Constant	Default value	Units
Actin filament backbone	Spring constant k	1,743	pN/nm
Myosin filament backbone	Spring constant k	2,020	pN/nm
Titin	Non-linear spring constant a	240	pN
	Non-linear spring constant b	0.0045	nm⁻¹
Myosin converter domain	Weak rest angle	0.8230972752	rad
	Strong rest angle	1.277581012	rad
	Weak torsional spring constant k	40	pN/rad
	Strong torsional spring constant k	40	pN/rad
Myosin globular domain	Weak rest length	19.93	nm
	Strong rest length	16.47	nm
	Weak spring constant k	2	pN/nm
	Strong spring constant k	2	pN/nm
Tropomyosin	Equilibrium constant K₁	1.47E+05	mol Ca⁻¹
	Equilibrium constant K₂	1.30E+02	-
	Equilibrium constant K₃	9.10E−01	-
	Forward rate constant r_t;12	1.70E+08	s⁻¹mol Ca⁻¹
	Forward rate constant r_t;23	1.40E+04	s⁻¹
	Forward rate constant r_t;34	2.00E+03	s⁻¹
	Forward rate constant r_t;41	110	s⁻¹
	Cooperative modifier	1	-

Component	Constant	Default value	Units
Actin filament backbone	Spring constant k	1,743	pN/nm
Myosin filament backbone	Spring constant k	2,020	pN/nm
Titin	Non-linear spring constant a	240	pN
	Non-linear spring constant b	0.0045	nm⁻¹
Myosin converter domain	Weak rest angle	0.8230972752	rad
	Strong rest angle	1.277581012	rad
	Weak torsional spring constant k	40	pN/rad
	Strong torsional spring constant k	40	pN/rad
Myosin globular domain	Weak rest length	19.93	nm
	Strong rest length	16.47	nm
	Weak spring constant k	2	pN/nm
	Strong spring constant k	2	pN/nm
Tropomyosin	Equilibrium constant K₁	1.47E+05	mol Ca⁻¹
	Equilibrium constant K₂	1.30E+02	-
	Equilibrium constant K₃	9.10E−01	-
	Forward rate constant r_t;12	1.70E+08	s⁻¹mol Ca⁻¹
	Forward rate constant r_t;23	1.40E+04	s⁻¹
	Forward rate constant r_t;34	2.00E+03	s⁻¹
	Forward rate constant r_t;41	110	s⁻¹
	Cooperative modifier	1	-

Mechanistic properties of the base model including mechanical and kinetic parameters are listed. These properties can also be found in the source code for the base model.

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