Table 1.

Base model parameters

ComponentConstantDefault valueUnits
Actin filament backbone Spring constant k 1,743 pN/nm 
Myosin filament backbone Spring constant k 2,020 pN/nm 
Titin Non-linear spring constant a 240 pN 
 Non-linear spring constant b 0.0045 nm−1 
Myosin converter domain Weak rest angle 0.8230972752 rad 
 Strong rest angle 1.277581012 rad 
 Weak torsional spring constant k 40 pN/rad 
 Strong torsional spring constant k 40 pN/rad 
Myosin globular domain Weak rest length 19.93 nm 
 Strong rest length 16.47 nm 
 Weak spring constant k pN/nm 
 Strong spring constant k pN/nm 
Tropomyosin Equilibrium constant K1 1.47E+05 mol Ca−1 
 Equilibrium constant K2 1.30E+02 
 Equilibrium constant K3 9.10E−01 
 Forward rate constant rt;12 1.70E+08 s−1mol Ca−1 
 Forward rate constant rt;23 1.40E+04 s−1 
 Forward rate constant rt;34 2.00E+03 s−1 
 Forward rate constant rt;41 110 s−1 
 Cooperative modifier 
ComponentConstantDefault valueUnits
Actin filament backbone Spring constant k 1,743 pN/nm 
Myosin filament backbone Spring constant k 2,020 pN/nm 
Titin Non-linear spring constant a 240 pN 
 Non-linear spring constant b 0.0045 nm−1 
Myosin converter domain Weak rest angle 0.8230972752 rad 
 Strong rest angle 1.277581012 rad 
 Weak torsional spring constant k 40 pN/rad 
 Strong torsional spring constant k 40 pN/rad 
Myosin globular domain Weak rest length 19.93 nm 
 Strong rest length 16.47 nm 
 Weak spring constant k pN/nm 
 Strong spring constant k pN/nm 
Tropomyosin Equilibrium constant K1 1.47E+05 mol Ca−1 
 Equilibrium constant K2 1.30E+02 
 Equilibrium constant K3 9.10E−01 
 Forward rate constant rt;12 1.70E+08 s−1mol Ca−1 
 Forward rate constant rt;23 1.40E+04 s−1 
 Forward rate constant rt;34 2.00E+03 s−1 
 Forward rate constant rt;41 110 s−1 
 Cooperative modifier 

Mechanistic properties of the base model including mechanical and kinetic parameters are listed. These properties can also be found in the source code for the base model.

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