Transcription factors with DNA binding sites over-represented in upregulated genes
| TF . | Description . | # of genes & (P value) . | References . |
|---|---|---|---|
| Sko1 | Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses | 44 (4.7E-12) | (Reimand et al., 2010; Niu et al., 2008; Ni et al., 2009) |
| Hot1 | Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p | 13 (1.2E-09) | |
| Spt23 | ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication | 58 (1.3E-08) | (Auld et al., 2006; Reimand et al., 2010) |
| Yap6 | Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication | 38 (6.22E-08) | (Lee et al., 2002; Harbison et al., 2004; Ni et al., 2009; Reimand et al., 2010) |
| Cad1 | AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication | 27 (1.01E-07) | (Mazzola et al., 2015; Reimand et al., 2010; Haugen et al., 2004; Lee et al., 2002; Azevedo et al., 2007) |
| Adr1 | Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization | 31 (8.55E-07) | (Chua et al., 2006; Reimand et al., 2010; Karpichev et al., 2008) |
| TF . | Description . | # of genes & (P value) . | References . |
|---|---|---|---|
| Sko1 | Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses | 44 (4.7E-12) | (Reimand et al., 2010; Niu et al., 2008; Ni et al., 2009) |
| Hot1 | Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p | 13 (1.2E-09) | |
| Spt23 | ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication | 58 (1.3E-08) | (Auld et al., 2006; Reimand et al., 2010) |
| Yap6 | Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication | 38 (6.22E-08) | (Lee et al., 2002; Harbison et al., 2004; Ni et al., 2009; Reimand et al., 2010) |
| Cad1 | AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication | 27 (1.01E-07) | (Mazzola et al., 2015; Reimand et al., 2010; Haugen et al., 2004; Lee et al., 2002; Azevedo et al., 2007) |
| Adr1 | Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization | 31 (8.55E-07) | (Chua et al., 2006; Reimand et al., 2010; Karpichev et al., 2008) |
Analysis of genes with >twofold increase in response to edelfosine (119 genes) as determined by Yeastract (Monteiro et al., 2020) using DNA binding evidence only. P values calculated using the hypergeometric test.