Properties of INa determined in Xenopus oocytes expressing NaV1.5 alone or in combination with iFGF12B or iFGF13VYa
| . | NaV1.5 . | NaV1.5 + iFGF12B . | NaV1.5 + iFGF13VY . |
|---|---|---|---|
| G-V activation (n) | (5) | (6) | (6) |
| V1/2, act (mV) | −37.0 ± 0.6 | −26.2 ± 2.2 | −32.3 ± 3.1 |
| P valueb | 0.006 (**) | 0.33 | |
| kact | 6.1 ± 0.3 | 6.6 ± 0.4 | 5.5 ± 0.5 |
| P valueb | 0.44 | 0.60 | |
| G-V inactivation (n) | (9) | (7) | (6) |
| V1/2, inact (mV) | −69.0 ± 0.5 | −60.9 ± 0.4 | −54.5 ± 1.8 |
| P valueb | <0.001 (***) | <0.001 (***) | |
| kinact | 5.8 ± 0.3 | 4.9 ± 0.3 | 4.7 ± 0.4 |
| P valueb | 0.06 | 0.09 | |
| Inactivation recovery (n) | (8) | (5) | (5) |
| ƬR,1 (ms) | 2.5 ± 0.2 | 1.9 ± 0.3 | 1.3 ± 0.1 |
| P valueb | 0.04 (*) | <0.001 (***) | |
| ƬR,2 (ms)c | 15.8 ± 1.4 | 12.5 ± 1.3 | 8.5 ± 1.3 |
| . | NaV1.5 . | NaV1.5 + iFGF12B . | NaV1.5 + iFGF13VY . |
|---|---|---|---|
| G-V activation (n) | (5) | (6) | (6) |
| V1/2, act (mV) | −37.0 ± 0.6 | −26.2 ± 2.2 | −32.3 ± 3.1 |
| P valueb | 0.006 (**) | 0.33 | |
| kact | 6.1 ± 0.3 | 6.6 ± 0.4 | 5.5 ± 0.5 |
| P valueb | 0.44 | 0.60 | |
| G-V inactivation (n) | (9) | (7) | (6) |
| V1/2, inact (mV) | −69.0 ± 0.5 | −60.9 ± 0.4 | −54.5 ± 1.8 |
| P valueb | <0.001 (***) | <0.001 (***) | |
| kinact | 5.8 ± 0.3 | 4.9 ± 0.3 | 4.7 ± 0.4 |
| P valueb | 0.06 | 0.09 | |
| Inactivation recovery (n) | (8) | (5) | (5) |
| ƬR,1 (ms) | 2.5 ± 0.2 | 1.9 ± 0.3 | 1.3 ± 0.1 |
| P valueb | 0.04 (*) | <0.001 (***) | |
| ƬR,2 (ms)c | 15.8 ± 1.4 | 12.5 ± 1.3 | 8.5 ± 1.3 |
Values are means ± SEM; n = number of biological replicates (cells).
P values are obtained from a comparison to recordings from oocytes expressing NaV1.5 alone (see Materials and methods). Significant differences are designated as *, **, and *** for P values <0.05, 0.01, and 0.001, respectively.
Recovery time constant for the slower component contributes very little. A comparison is thus omitted.