Properties of INa in LV myocytes isolated from various mouse linesa
| . | WT . | Fgf13 floxed . | cFgf13KO . | cFgf13KO + iFGF12B . | Fgf12KO . |
|---|---|---|---|---|---|
| G-V activation (n) | (24 cells, 7 mice) | (15 cells, 6 mice) | (26 cells, 8 mice) | (19 cells, 4 mice) | (19 cells, 6 mice) |
| V1/2, act (mV) | −46.3 ± 0.6 | −44.1 ± 1.0 | −44.4 ± 0.6 | −37.48 ± 0.9 | −44.6 ± 0.8 |
| P valueb | 0.45 | 0.28 | <0.001 (***) | 0.69 | |
| P valuec | 0.99 | <0.001 (***) | 0.99 | ||
| P valued | <0.001 (***) | ||||
| kact | 3.6 ± 0.1 | 2.9 ± 0.2 | 4.0 ± 0.1 | 4.3 ± 0.1 | 3.7 ± 0.2 |
| P valueb | 0.93 | 0.17 | 0.002 (**) | 0.99 | |
| P-valuec | 0.99 | 0.73 | 0.99 | ||
| P valued | 0.51 | ||||
| G-V inactivation (n) | (24 cells, 7 mice) | (15 cells, 6 mice) | (26 cells, 8 mice) | (17 cells, 4 mice) | (19 cells, 6 mice) |
| V1/2, inact (mV) | −73.4 ± 1.0 | −72.8 ± 1.3 | −82.5 ± 0.8 | −77.2 ± 0.5 | −70.1 ± 1.0 |
| P valueb | 0.99 | <0.001 (***) | 0.028 (*) | 0.26 | |
| P valuec | <0.001 (***) | 0.05 (*) | 0.67 | ||
| P valued | <0.001 (***) | ||||
| kinact | 7.2 ± 0.1 | 7.1 ± 0.1 | 6.7 ± 0.2 | 6.9 ± 0.1 | 7.2 ± 0.1 |
| P valueb | 0.99 | 0.10 | 0.23 | 0.99 | |
| P valuec | 0.62 | 0.92 | 0.99 | ||
| P valued | 0.19 | ||||
| Inactivation recovery (n) | (9 cells, 2 mice) | (9 cells, 2 mice) | (9 cells, 2 mice) | ||
| ƬR,1 (ms) | 8.2 ± 1.3 | 6.3 ± 0.9 | 4.0 ± 0.6 | ||
| P valueb | 0.38 | 0.015 (**) | |||
| P valued | 0.04 (*) | ||||
| ƬR,2 (ms)e | 85.4 ± 18.1 | 58.9 ± 8.4 | 28.2 ± 2.8 |
| . | WT . | Fgf13 floxed . | cFgf13KO . | cFgf13KO + iFGF12B . | Fgf12KO . |
|---|---|---|---|---|---|
| G-V activation (n) | (24 cells, 7 mice) | (15 cells, 6 mice) | (26 cells, 8 mice) | (19 cells, 4 mice) | (19 cells, 6 mice) |
| V1/2, act (mV) | −46.3 ± 0.6 | −44.1 ± 1.0 | −44.4 ± 0.6 | −37.48 ± 0.9 | −44.6 ± 0.8 |
| P valueb | 0.45 | 0.28 | <0.001 (***) | 0.69 | |
| P valuec | 0.99 | <0.001 (***) | 0.99 | ||
| P valued | <0.001 (***) | ||||
| kact | 3.6 ± 0.1 | 2.9 ± 0.2 | 4.0 ± 0.1 | 4.3 ± 0.1 | 3.7 ± 0.2 |
| P valueb | 0.93 | 0.17 | 0.002 (**) | 0.99 | |
| P-valuec | 0.99 | 0.73 | 0.99 | ||
| P valued | 0.51 | ||||
| G-V inactivation (n) | (24 cells, 7 mice) | (15 cells, 6 mice) | (26 cells, 8 mice) | (17 cells, 4 mice) | (19 cells, 6 mice) |
| V1/2, inact (mV) | −73.4 ± 1.0 | −72.8 ± 1.3 | −82.5 ± 0.8 | −77.2 ± 0.5 | −70.1 ± 1.0 |
| P valueb | 0.99 | <0.001 (***) | 0.028 (*) | 0.26 | |
| P valuec | <0.001 (***) | 0.05 (*) | 0.67 | ||
| P valued | <0.001 (***) | ||||
| kinact | 7.2 ± 0.1 | 7.1 ± 0.1 | 6.7 ± 0.2 | 6.9 ± 0.1 | 7.2 ± 0.1 |
| P valueb | 0.99 | 0.10 | 0.23 | 0.99 | |
| P valuec | 0.62 | 0.92 | 0.99 | ||
| P valued | 0.19 | ||||
| Inactivation recovery (n) | (9 cells, 2 mice) | (9 cells, 2 mice) | (9 cells, 2 mice) | ||
| ƬR,1 (ms) | 8.2 ± 1.3 | 6.3 ± 0.9 | 4.0 ± 0.6 | ||
| P valueb | 0.38 | 0.015 (**) | |||
| P valued | 0.04 (*) | ||||
| ƬR,2 (ms)e | 85.4 ± 18.1 | 58.9 ± 8.4 | 28.2 ± 2.8 |
Values are means ± SEM; n = number of biological replicates (cells and mice).
P values are obtained from a comparison to recordings in WT LV myocytes (see Materials and methods). Significant differences are designated as *, **, and *** for P values <0.05, 0.01, and 0.001, respectively.
P values are obtained from a comparison to recordings in Fgf13 floxed LV myocytes. Significant differences are designated as *, **, and *** for P values <0.05, 0.01, and 0.001, respectively.
P values are obtained from a comparison to recordings in cFgf13KO LV myocytes. Significant differences are designated as *, **, and *** for P values <0.05, 0.01, and 0.001, respectively.
Recovery time constant for the slower component contributes very little. A comparison is thus omitted.