Calculated conductances from MD simulations of ion permeation in non-selective TRPV channels
| . | Conductance (pS) . | |||
|---|---|---|---|---|
| Ca2+ . | Na+ . | Ca2+ & Na+ . | Experimental literature values . | |
| TRPV2 | 40 ± 4 | 18 ± 3 | 43 ± 7 | 28 (Na+) (Zhang et al., 2016) |
| TRPV3 | 196 ± 10 | 299 ± 10 | 222 ± 13 | 201 (Na+) (Chung et al., 2004) |
| . | Conductance (pS) . | |||
|---|---|---|---|---|
| Ca2+ . | Na+ . | Ca2+ & Na+ . | Experimental literature values . | |
| TRPV2 | 40 ± 4 | 18 ± 3 | 43 ± 7 | 28 (Na+) (Zhang et al., 2016) |
| TRPV3 | 196 ± 10 | 299 ± 10 | 222 ± 13 | 201 (Na+) (Chung et al., 2004) |
Mean inward conductances and SEM were calculated from overlapping 50 ns windows from fivefold replicated 250 ns simulations. Monocationic solutions at 150 mM concentration; dicationic mixture of Ca2+ and Na+ at a concentration of 75 mM each.