Table 3. Calculated conductances from MD... | Rockefeller University Press

Table 3.

Calculated conductances from MD simulations of ion permeation in Ca²⁺-selective TRPV channels

	Conductance (pS)
	Ca²⁺	Na⁺	Ca²⁺ and Na⁺	Experimental literature values
TRPV5	53 ± 7	49 ± 6	92 ± 10	59 ± 6 (Na⁺) (Cha et al., 2007)
TRPV6	117 ± 12	61 ± 6	29 ± 6	58 ± 4 (Na⁺) (Yue et al., 2001)

	Conductance (pS)
	Ca²⁺	Na⁺	Ca²⁺ and Na⁺	Experimental literature values
TRPV5	53 ± 7	49 ± 6	92 ± 10	59 ± 6 (Na⁺) (Cha et al., 2007)
TRPV6	117 ± 12	61 ± 6	29 ± 6	58 ± 4 (Na⁺) (Yue et al., 2001)

Mean inward conductances and SEM were calculated from overlapping 50 ns windows from fivefold replicated 250 ns simulations. Permeation of monocationic Ca²⁺ or Na⁺ cations was simulated in a solution of 150 mM CaCl₂ or 150 mM NaCl, respectively. Permeation of a dicationic mixture of Ca²⁺ and Na⁺ cations was investigated in a solution of 75 mM CaCl₂ and 75 mM NaCl.

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