Table 1.

Number of published GWAS studies linking polymorphisms (SNPs) in STAT6 to common allergic diseases in the population

PhenotypeNumber of published associationsReferences
Asthmaa 14 Daya et al., 2019; Demenais et al., 2018; Ferreira et al., 2019; Han et al., 2020; Johansson et al., 2019; Olafsdottir et al., 2020; Pickrell et al., 2016; Pividori et al., 2019; Sakaue et al., 2021; Shrine et al., 2019; Valette et al., 2021; Zhu et al., 2020; Zhu et al., 2018; Zhu et al., 2019  
Eosinophil count Astle et al., 2016; Chen et al., 2020; Höglund et al., 2022; Kachuri et al., 2021; Kichaev et al., 2019; Sakaue et al., 2021; Vuckovic et al., 2020  
Allergic disease Ferreira et al., 2017; Ferreira et al., 2020; Zhu et al., 2018  
Atopic dermatitis/eczema Johansson et al., 2019; Kichaev et al., 2019; Tanaka et al., 2021  
Serum IgE level Daya et al., 2021; Granada et al., 2012  
Allergic sensitization Bønnelykke et al., 2013; Waage et al., 2018  
Allergic rhinitis Johansson et al., 2019  
Eosinophilic gastrointestinal disorders Sleiman et al., 2014  
PhenotypeNumber of published associationsReferences
Asthmaa 14 Daya et al., 2019; Demenais et al., 2018; Ferreira et al., 2019; Han et al., 2020; Johansson et al., 2019; Olafsdottir et al., 2020; Pickrell et al., 2016; Pividori et al., 2019; Sakaue et al., 2021; Shrine et al., 2019; Valette et al., 2021; Zhu et al., 2020; Zhu et al., 2018; Zhu et al., 2019  
Eosinophil count Astle et al., 2016; Chen et al., 2020; Höglund et al., 2022; Kachuri et al., 2021; Kichaev et al., 2019; Sakaue et al., 2021; Vuckovic et al., 2020  
Allergic disease Ferreira et al., 2017; Ferreira et al., 2020; Zhu et al., 2018  
Atopic dermatitis/eczema Johansson et al., 2019; Kichaev et al., 2019; Tanaka et al., 2021  
Serum IgE level Daya et al., 2021; Granada et al., 2012  
Allergic sensitization Bønnelykke et al., 2013; Waage et al., 2018  
Allergic rhinitis Johansson et al., 2019  
Eosinophilic gastrointestinal disorders Sleiman et al., 2014  

Significant genome-wide associations (P < 5 × 10−8) between STAT6 SNPs and all relevant allergic traits were obtained through the National Human Genome Research Institute–European Bioinformatics Institute GWAS Catalog (https://www.ebi.ac.uk/gwas/).

a

Includes asthma, childhood-onset asthma, adult-onset asthma, and atopic asthma.

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