Table 2.

Pathological and non-pathological systems featuring mitochondrial transfer

ConditionResultReference
Pathological Lung carcinoma Rescued mitochondrial function Spees et al., 2006  
 Osteosarcoma Rescued mitochondrial function Cho et al., 2012  
 Acute lung injury Cellular protection and tissue repair Islam et al., 2012  
 Ischemia Preserving myocardial energetics, cell viability, and enhanced post-infarct cardiac function—protect the heart from ischemia-reperfusion injury Masuzawa et al., 2013  
 Allergic airway inflammation Enhanced rescue of epithelial injury Ahmad et al., 2014  
 Chronic obstructive pulmonary disease Attenuation of cigarette smoke–induced lung damage Li et al., 2014  
 Ischemia Cardioprotection from ischemia-reperfusion injury Cowan et al., 2016  
 Cerebral ischemia Amplified cell survival signals—neurorecovery Hayakawa et al., 2016  
 Acute respiratory distress syndrome Enhancement of phagocytic activity of lung alveolar macrophages Jackson et al., 2016a; Jackson et al., 2016b  
 Acute myeloid leukemia Resistance to chemotherapy Moschoi et al., 2016  
 Canine transmissible venereal tumor Acquisition of functional mtDNA Strakova et al., 2016, 2020  
 Bladder cancer Increased invasiveness Lu et al., 20178 
 Acute respiratory distress syndrome Anti-inflammatory and highly phagocytic macrophage phenotype resulting in amelioration of lung injury Morrison et al., 2017  
 PD Acquisition of functional mitochondria Rostami et al., 2017  
 Oxygen-glucose deprivation Restoring brain endothelial energetics and barrier integrity Hayakawa et al., 2018  
 Hypoxia/reoxygenation injury Attenuation of CM apoptosis Shen et al., 2018  
 Asthma Alleviated asthmatic inflammation Yao et al., 2018  
 Diabetic nephropathy Structural and functional restoration of renal proximal tubular epithelial cells Konari et al., 2019  
 MM Enhanced mitochondrial metabolism, protumoral effect Marlein et al., 2019  
 Neonatal cardiomyopathy Improvement of CM bioenergetics and viability in male rats exposed to pre-gestational diabetes Louwagie et al., 2021  
 Lung carcinoma Enhancement of metastatic potential during tumor progression Takenaga et al., 2021  
 Cerebral ischemia Increased neuronal survival and improved metabolism Tseng et al., 2021  
 Glioblastoma Adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions Valdebenito et al., 2021  
 AD Increased transmitophagy of defective neuronal mitochondrial, potential alleviation of AD pathology and symptoms Lampinen et al., 2022  
Non-pathological Cardiac homeostasis Preserved metabolic stability and organ function Nicolas-Avila et al., 2020  
 White adipose tissue homeostasis Metabolic homeostasis, impairment leads to obesity Brestoff et al., 2021  
 Metabolic preconditioning of the heart Cardio-protection against lipotoxic or ischemic stresses elicited by obesity Crewe et al., 2021  
 Wound healing Promotion of pro-angiogenic activity of MSCs via their metabolic remodeling Levoux et al., 2021  
ConditionResultReference
Pathological Lung carcinoma Rescued mitochondrial function Spees et al., 2006  
 Osteosarcoma Rescued mitochondrial function Cho et al., 2012  
 Acute lung injury Cellular protection and tissue repair Islam et al., 2012  
 Ischemia Preserving myocardial energetics, cell viability, and enhanced post-infarct cardiac function—protect the heart from ischemia-reperfusion injury Masuzawa et al., 2013  
 Allergic airway inflammation Enhanced rescue of epithelial injury Ahmad et al., 2014  
 Chronic obstructive pulmonary disease Attenuation of cigarette smoke–induced lung damage Li et al., 2014  
 Ischemia Cardioprotection from ischemia-reperfusion injury Cowan et al., 2016  
 Cerebral ischemia Amplified cell survival signals—neurorecovery Hayakawa et al., 2016  
 Acute respiratory distress syndrome Enhancement of phagocytic activity of lung alveolar macrophages Jackson et al., 2016a; Jackson et al., 2016b  
 Acute myeloid leukemia Resistance to chemotherapy Moschoi et al., 2016  
 Canine transmissible venereal tumor Acquisition of functional mtDNA Strakova et al., 2016, 2020  
 Bladder cancer Increased invasiveness Lu et al., 20178 
 Acute respiratory distress syndrome Anti-inflammatory and highly phagocytic macrophage phenotype resulting in amelioration of lung injury Morrison et al., 2017  
 PD Acquisition of functional mitochondria Rostami et al., 2017  
 Oxygen-glucose deprivation Restoring brain endothelial energetics and barrier integrity Hayakawa et al., 2018  
 Hypoxia/reoxygenation injury Attenuation of CM apoptosis Shen et al., 2018  
 Asthma Alleviated asthmatic inflammation Yao et al., 2018  
 Diabetic nephropathy Structural and functional restoration of renal proximal tubular epithelial cells Konari et al., 2019  
 MM Enhanced mitochondrial metabolism, protumoral effect Marlein et al., 2019  
 Neonatal cardiomyopathy Improvement of CM bioenergetics and viability in male rats exposed to pre-gestational diabetes Louwagie et al., 2021  
 Lung carcinoma Enhancement of metastatic potential during tumor progression Takenaga et al., 2021  
 Cerebral ischemia Increased neuronal survival and improved metabolism Tseng et al., 2021  
 Glioblastoma Adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions Valdebenito et al., 2021  
 AD Increased transmitophagy of defective neuronal mitochondrial, potential alleviation of AD pathology and symptoms Lampinen et al., 2022  
Non-pathological Cardiac homeostasis Preserved metabolic stability and organ function Nicolas-Avila et al., 2020  
 White adipose tissue homeostasis Metabolic homeostasis, impairment leads to obesity Brestoff et al., 2021  
 Metabolic preconditioning of the heart Cardio-protection against lipotoxic or ischemic stresses elicited by obesity Crewe et al., 2021  
 Wound healing Promotion of pro-angiogenic activity of MSCs via their metabolic remodeling Levoux et al., 2021  
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