Table 1. Overview of donor/acceptor... | Rockefeller University Press

Table 1.

Overview of donor/acceptor cells (types of cells) involved in mitochondrial transfer

Donor cells	Acceptor cells	Type of transfer	References
Rat neuroendocrine pheochromocytoma cells	Rat neuroendocrine pheochromocytoma cells	TNTs	Rustom et al., 2004
Human embryonic kidney cells	Human embryonic kidney cells	TNTs	Rustom et al., 2004
Normal rat kidney cells	Normal rat kidney cells	TNTs	Rustom et al., 2004
Rat neonatal CMs	Human endothelial progenitor cells	Nanotubes	Koyanagi et al., 2005
Human macrophage	Human macrophages	TNTs	Onfelt et al., 2006
Human MSCs	Human alveolar adenocarcinoma cells	TNTs	Spees et al., 2006
Human skin fibroblast	Human alveolar adenocarcinoma cells	TNTs	Spees et al., 2006
Human MSCs	Rat CM	Nanotubes	Plotnikov et al., 2008
Rat MSCs	Rat lung ECs	Cx43-based intercellular gap junctional communication	Otsu et al., 2009
MSCs	Rat cardiomyoblasts	Nanotubes	Cselenyak et al., 2010
Rat kidney renal tubular cells	Human MSCs	TNTs and gap junctions	Plotnikov et al., 2010
Human MSCs	Rat kidney renal tubular cells	TNTs and gap junctions	Plotnikov et al., 2010
Mouse endothelial progenitor cells	Human umbilical vein ECs	TNTs	Yasuda et al., 2010
Human adipose-derived stem cells	Mouse CMs	Partial cell fusion	Acquistapace et al., 2011
Human proximal tubular epithelial cells	Human proximal tubular epithelial cells	TNT-like structures	Domhan et al., 2011
Rat ventricular CMs	Rat fibroblasts	Nanotubes	He et al., 2011
Rat ventricular CMs	Rat ventricular CMs	Nanotubes	He et al., 2011
Rat fibroblasts	Rat fibroblasts	Nanotubes	He et al., 2011
Rat fibroblasts	Rat ventricular CMs	Nanotubes	He et al., 2011
Rat hippocampal astrocytes	Rat hippocampal astrocytes	TNTs	Wang et al., 2011
Human MSCs	Human osteosarcoma cells	Partial cell fusion	Cho et al., 2012
Mouse BM-derived stromal cells	Mouse BM-derived stromal cells	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human BM-derived stromal cells	Human BM-derived stromal cells	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Mouse BM-derived stromal cells^*	Mouse alveolar epithelial cell^*	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human BM-derived stromal cells^*	Mouse alveolar epithelial cell^*	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human pleural mesothelioma cells	Human pleural mesothelioma cells	TNTs	Lou et al., 2012
Human MSCs	Human vascular smooth muscle cells	TNTs	Vallabhaneni et al., 2012
Human vascular smooth muscle cells	Human MSCs	TNTs	Vallabhaneni et al., 2012
Human retinal pigment epithelial cells	Human retinal pigment epithelial cells	TNTs	Witting et al., 2012)
Human ECs	Human ovarian cancer cells	TNTs	Pasquier et al., 2013
Human ECs	Human breast cancer cells	TNTs	Pasquier et al., 2013
MSC^*	Bronchial epithelial cells^*	TNTs	Ahmad et al., 2014
Platelets	Neutrophils	ECVs	Boudreau et al., 2014
Murine neuronal cells^*	Murine glial cells^*	Protrusions	Davis et al., 2014
MSCs^*	Lung epithelial cells^*	TNTs	Li et al., 2014
MSCs	Human umbilical vein ECs	TNTs	Li et al., 2014
Human multipotent MSCs	Rat neuronal cells	Intercellular contacts	Babenko et al., 2015
Human multipotent MSCs	Rat glial cells	Intercellular contacts	Babenko et al., 2015
Breast cancer cells	Breast cancer cells	n.s.	Jayaprakash et al., 2015
Normal fibroblast cells	Normal fibroblast cells	n.s.	Jayaprakash et al., 2015
Human MSCs	Macrophages	MVs	Phinney et al., 2015
Human MSCs^*	Macrophages^*	MVs	Phinney et al., 2015
Pheochromocytoma cells	Pheochromocytoma cells	TNTs	Okafo et al., 2017
MSCs	Rat cardiomyoblasts	TNTs	Han et al., 2016
Astrocytes^*	Neuronal cells^*	Extracellular mitochondrial particles	Hayakawa et al., 2016
MSCs^*	Lung alveolar macrophages^*	TNTs	Jackson et al., 2016a, b
MSCs	Corneal epithelial cells	TNTs	Jiang et al., 2016
Mouse sister germ cells	Mouse oocytes	Microtubes	Lei and Spradling, 2016
BM stromal cells	Acute myeloid leukemic cells	Endocytosis	Moschoi et al., 2016
BM stromal cells^*	Acute myeloid leukemic cells^*	Endocytosis	Moschoi et al., 2016
MSCs^*	Murine CMs^*	TNTs	Zhang et al., 2016
MSCs	Murine CMs	TNTs	Zhang et al., 2016
MSCs	MERRF cybrid cells	n.s.	Chuang et al., 2017
Malignant urothelial carcinoma cells	Non-malignant urinary papillary urothelial tumor cells	TNTs	Lu et al., 2017
Human MSCs	Human CMs	n.s.	Mahrouf-Yorgov et al., 2017
Human MSCs	Human ECs	n.s.	Mahrouf-Yorgov et al., 2017
Human CMs	Human MSCs	n.s.	Mahrouf-Yorgov et al., 2017
Human ECs	Human MSCs	n.s.	Mahrouf-Yorgov et al., 2017
BM stromal cells^*	Acute myeloid leukemia cells^*	TNTs	Marlein et al., 2017
Mesenchymal stromal cells^*	Macrophages^*	EVs	Morrison et al., 2017
Human healthy astrocytes	Human stressed astrocytes	TNTs	Rostami et al., 2017
Human multipotent MSCs	Rat astrocytes	TNTs	Babenko et al., 2018
Human multipotent MSCs	Neuron-like PC12 pheochromocytoma ρ0 cells	TNTs	Babenko et al., 2018
MSCs	Neural stem cells	Actin-based intercellular structures	Boukelmoune et al., 2018
Monkey kidney cells	Monkey kidney cells	TNTs	Guo et al., 2018
Porcine alveolar macrophages	Porcine alveolar macrophages	TNTs	Guo et al., 2018
Porcine umbilical cord MSCs	Porcine alveolar macrophages	TNTs	Guo et al., 2018
Endothelial progenitor cells	Brain ECs	Endothelial progenitor cell–derived mitochondrial particles	Hayakawa et al., 2018
Myeloid-derived regulatory cells	T Cells	ECVs	Hough et al., 2018
Cardiac myofibroblasts	Cardiomyocytes	Nanotubes	Shen et al., 2018
T cell acute lymphoblastic leukemia cells	MSCs	TNTs	Wang e al., 2018
MSCs	T Cell acute lymphoblastic leukemia cells	TNTs	Wang et al., 2018
Human induced pluripotent stem cell–derived MSCs	Human bronchial epithelium cells	TNTs (Cx43 mediated)	Yao et al., 2018
Human induced pluripotent stem cell–derived MSCs^*	Murine epithelial cells^*	TNTs (Cx43 mediated)	Yao et al., 2018
Scattered tubular-like cells	Tubular epithelial cells	ECVs	Zou et al., 2018
MSCs	Acute lymphoblastic leukemia cells	TNTs	Burt et al., 2019
BM MSCs	Human ECs	TNTs	Feng et al., 2019
Human astrocytes	Human astrocytes	n.s.	Gao et al., 2019
Human neuronal cells	Human astrocytes	n.s.	Gao et al., 2019
Cancer-associated fibroblasts	Prostate cancer cells	Cellular bridges	Ippolito et al., 2019
Cancer-associated fibroblasts^*	Prostate cancer cells^*	Cellular bridges	Ippolito et al., 2019
BM-derived MSCs	Proximal tubular epithelial cells	n.s.	Konari et al., 2019
BM-derived MSCs^*	Proximal tubular epithelial cells^*	n.s.	Konari et al., 2019
Rat MSCs	Rat neurons	Gap junction intercellular communication	Li et al., 2019
Rat MSCs^*	Rat neurons^*	Gap junction intercellular communication	Li et al., 2019
Astrocytes	Primary rat neuronal cells	n.s.	Lippert and Borlongan, 2019
BM stromal cells	MM cells	TNTs	Marlein et al., 2019
BM stromal cells	Hematopoietic stem cells	Gap junction	Mistry et al., 2019
BM stromal cells^*	Hematopoietic stem cells^*	Gap junction	Mistry et al., 2019
Astrocytes	Neurons	n.s.	English et al., 2020
Murine hematopoietic stem and progenitor cells^*	Murine mesenchymal stromal cells^*	Cell-contact dependent, Cx43-mediated	Golan et al., 2020
Murine CMs^*	Murine macrophages^*	Cardiomyocyte-derived exophers (subcellular particles)	Nocolas-Avila et al., 2020
Mesenchymal stromal cells	Islet β cells	TNTs	Rackham et al., 2020
Murine white adipocytes^*	Murine macrophages^*	n.s.	Brestoff et al., 2021
Human MSCs	Injured alveolar epithelial cells	Cx43-containing gap junctional channels	Huang et al., 2021
Platelets	MSCs	Dynamin-dependent clathrin-mediated endocytosis	Levoux et al., 2021
Platelets^*	MSCs^*	Dynamin-dependent clathrin-mediated endocytosis	Levoux et al., 2021
BM stromal cells	Myeloma cells	TNTs and partial cell fusion	Matula et al., 2021
Myeloma cells	BM stromal cells	TNTs and partial cell fusion	Matula et al., 2021
Murine ovarian follicles	Murine ovarian follicles	Gap junction internalization	Norris, 2021
Glioblastoma stem cells	Glioblastoma stem cells	TNTs	Pinto et al., 2021
3D-glioblastoma organoids	3D-glioblastoma organoids	TNTs	Pinto et al., 2021
Human breast epithelial cancer cells	Human breast epithelial cancer cells	ECVs	Rabas et al., 2021
Murine high-metastatic lung carcinoma cells	Murine low-metastatic lung carcinoma cells	ECVs	Takenaga et al., 2021
Murine low-metastatic lung carcinoma cells	Murine high-metastatic lung carcinoma cells	ECVs	Takenaga et al., 2021
Murine high-metastatic lung carcinoma cells^*	Murine low-metastatic lung carcinoma cells and cancer-associated fibroblasts^*	ECVs	Takenaga et al., 2021
MSCs	Neurons	Cell-to-cell contact	Tseng et al., 2021
Human glioblastoma cells	Human primary astrocytes	TNTs	Valdebenito et al., 2021
Human neurons	Human astrocytes	TNTs	Lampinen et al., 2022
Murine neurons	Murine astrocytes	TNTs	Lampinen et al., 2022
Murine brown adipocytes^*	Murine adipocytes^*	ECVs	Rosina et al., 2022
Effector immune cells	Breast cancer cells	TNTs	Saha et al., 2022
T cells^*	Lung carcinoma cells^*	TNTs	Saha et al., 2022
T cells^*	Melanoma cells^*	TNTs	Saha et al., 2022

Donor cells	Acceptor cells	Type of transfer	References
Rat neuroendocrine pheochromocytoma cells	Rat neuroendocrine pheochromocytoma cells	TNTs	Rustom et al., 2004
Human embryonic kidney cells	Human embryonic kidney cells	TNTs	Rustom et al., 2004
Normal rat kidney cells	Normal rat kidney cells	TNTs	Rustom et al., 2004
Rat neonatal CMs	Human endothelial progenitor cells	Nanotubes	Koyanagi et al., 2005
Human macrophage	Human macrophages	TNTs	Onfelt et al., 2006
Human MSCs	Human alveolar adenocarcinoma cells	TNTs	Spees et al., 2006
Human skin fibroblast	Human alveolar adenocarcinoma cells	TNTs	Spees et al., 2006
Human MSCs	Rat CM	Nanotubes	Plotnikov et al., 2008
Rat MSCs	Rat lung ECs	Cx43-based intercellular gap junctional communication	Otsu et al., 2009
MSCs	Rat cardiomyoblasts	Nanotubes	Cselenyak et al., 2010
Rat kidney renal tubular cells	Human MSCs	TNTs and gap junctions	Plotnikov et al., 2010
Human MSCs	Rat kidney renal tubular cells	TNTs and gap junctions	Plotnikov et al., 2010
Mouse endothelial progenitor cells	Human umbilical vein ECs	TNTs	Yasuda et al., 2010
Human adipose-derived stem cells	Mouse CMs	Partial cell fusion	Acquistapace et al., 2011
Human proximal tubular epithelial cells	Human proximal tubular epithelial cells	TNT-like structures	Domhan et al., 2011
Rat ventricular CMs	Rat fibroblasts	Nanotubes	He et al., 2011
Rat ventricular CMs	Rat ventricular CMs	Nanotubes	He et al., 2011
Rat fibroblasts	Rat fibroblasts	Nanotubes	He et al., 2011
Rat fibroblasts	Rat ventricular CMs	Nanotubes	He et al., 2011
Rat hippocampal astrocytes	Rat hippocampal astrocytes	TNTs	Wang et al., 2011
Human MSCs	Human osteosarcoma cells	Partial cell fusion	Cho et al., 2012
Mouse BM-derived stromal cells	Mouse BM-derived stromal cells	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human BM-derived stromal cells	Human BM-derived stromal cells	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Mouse BM-derived stromal cells^*	Mouse alveolar epithelial cell^*	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human BM-derived stromal cells^*	Mouse alveolar epithelial cell^*	Cx43-containing gap junctional channels, nanotubes, MVs	Islam et al., 2012
Human pleural mesothelioma cells	Human pleural mesothelioma cells	TNTs	Lou et al., 2012
Human MSCs	Human vascular smooth muscle cells	TNTs	Vallabhaneni et al., 2012
Human vascular smooth muscle cells	Human MSCs	TNTs	Vallabhaneni et al., 2012
Human retinal pigment epithelial cells	Human retinal pigment epithelial cells	TNTs	Witting et al., 2012)
Human ECs	Human ovarian cancer cells	TNTs	Pasquier et al., 2013
Human ECs	Human breast cancer cells	TNTs	Pasquier et al., 2013
MSC^*	Bronchial epithelial cells^*	TNTs	Ahmad et al., 2014
Platelets	Neutrophils	ECVs	Boudreau et al., 2014
Murine neuronal cells^*	Murine glial cells^*	Protrusions	Davis et al., 2014
MSCs^*	Lung epithelial cells^*	TNTs	Li et al., 2014
MSCs	Human umbilical vein ECs	TNTs	Li et al., 2014
Human multipotent MSCs	Rat neuronal cells	Intercellular contacts	Babenko et al., 2015
Human multipotent MSCs	Rat glial cells	Intercellular contacts	Babenko et al., 2015
Breast cancer cells	Breast cancer cells	n.s.	Jayaprakash et al., 2015
Normal fibroblast cells	Normal fibroblast cells	n.s.	Jayaprakash et al., 2015
Human MSCs	Macrophages	MVs	Phinney et al., 2015
Human MSCs^*	Macrophages^*	MVs	Phinney et al., 2015
Pheochromocytoma cells	Pheochromocytoma cells	TNTs	Okafo et al., 2017
MSCs	Rat cardiomyoblasts	TNTs	Han et al., 2016
Astrocytes^*	Neuronal cells^*	Extracellular mitochondrial particles	Hayakawa et al., 2016
MSCs^*	Lung alveolar macrophages^*	TNTs	Jackson et al., 2016a, b
MSCs	Corneal epithelial cells	TNTs	Jiang et al., 2016
Mouse sister germ cells	Mouse oocytes	Microtubes	Lei and Spradling, 2016
BM stromal cells	Acute myeloid leukemic cells	Endocytosis	Moschoi et al., 2016
BM stromal cells^*	Acute myeloid leukemic cells^*	Endocytosis	Moschoi et al., 2016
MSCs^*	Murine CMs^*	TNTs	Zhang et al., 2016
MSCs	Murine CMs	TNTs	Zhang et al., 2016
MSCs	MERRF cybrid cells	n.s.	Chuang et al., 2017
Malignant urothelial carcinoma cells	Non-malignant urinary papillary urothelial tumor cells	TNTs	Lu et al., 2017
Human MSCs	Human CMs	n.s.	Mahrouf-Yorgov et al., 2017
Human MSCs	Human ECs	n.s.	Mahrouf-Yorgov et al., 2017
Human CMs	Human MSCs	n.s.	Mahrouf-Yorgov et al., 2017
Human ECs	Human MSCs	n.s.	Mahrouf-Yorgov et al., 2017
BM stromal cells^*	Acute myeloid leukemia cells^*	TNTs	Marlein et al., 2017
Mesenchymal stromal cells^*	Macrophages^*	EVs	Morrison et al., 2017
Human healthy astrocytes	Human stressed astrocytes	TNTs	Rostami et al., 2017
Human multipotent MSCs	Rat astrocytes	TNTs	Babenko et al., 2018
Human multipotent MSCs	Neuron-like PC12 pheochromocytoma ρ0 cells	TNTs	Babenko et al., 2018
MSCs	Neural stem cells	Actin-based intercellular structures	Boukelmoune et al., 2018
Monkey kidney cells	Monkey kidney cells	TNTs	Guo et al., 2018
Porcine alveolar macrophages	Porcine alveolar macrophages	TNTs	Guo et al., 2018
Porcine umbilical cord MSCs	Porcine alveolar macrophages	TNTs	Guo et al., 2018
Endothelial progenitor cells	Brain ECs	Endothelial progenitor cell–derived mitochondrial particles	Hayakawa et al., 2018
Myeloid-derived regulatory cells	T Cells	ECVs	Hough et al., 2018
Cardiac myofibroblasts	Cardiomyocytes	Nanotubes	Shen et al., 2018
T cell acute lymphoblastic leukemia cells	MSCs	TNTs	Wang e al., 2018
MSCs	T Cell acute lymphoblastic leukemia cells	TNTs	Wang et al., 2018
Human induced pluripotent stem cell–derived MSCs	Human bronchial epithelium cells	TNTs (Cx43 mediated)	Yao et al., 2018
Human induced pluripotent stem cell–derived MSCs^*	Murine epithelial cells^*	TNTs (Cx43 mediated)	Yao et al., 2018
Scattered tubular-like cells	Tubular epithelial cells	ECVs	Zou et al., 2018
MSCs	Acute lymphoblastic leukemia cells	TNTs	Burt et al., 2019
BM MSCs	Human ECs	TNTs	Feng et al., 2019
Human astrocytes	Human astrocytes	n.s.	Gao et al., 2019
Human neuronal cells	Human astrocytes	n.s.	Gao et al., 2019
Cancer-associated fibroblasts	Prostate cancer cells	Cellular bridges	Ippolito et al., 2019
Cancer-associated fibroblasts^*	Prostate cancer cells^*	Cellular bridges	Ippolito et al., 2019
BM-derived MSCs	Proximal tubular epithelial cells	n.s.	Konari et al., 2019
BM-derived MSCs^*	Proximal tubular epithelial cells^*	n.s.	Konari et al., 2019
Rat MSCs	Rat neurons	Gap junction intercellular communication	Li et al., 2019
Rat MSCs^*	Rat neurons^*	Gap junction intercellular communication	Li et al., 2019
Astrocytes	Primary rat neuronal cells	n.s.	Lippert and Borlongan, 2019
BM stromal cells	MM cells	TNTs	Marlein et al., 2019
BM stromal cells	Hematopoietic stem cells	Gap junction	Mistry et al., 2019
BM stromal cells^*	Hematopoietic stem cells^*	Gap junction	Mistry et al., 2019
Astrocytes	Neurons	n.s.	English et al., 2020
Murine hematopoietic stem and progenitor cells^*	Murine mesenchymal stromal cells^*	Cell-contact dependent, Cx43-mediated	Golan et al., 2020
Murine CMs^*	Murine macrophages^*	Cardiomyocyte-derived exophers (subcellular particles)	Nocolas-Avila et al., 2020
Mesenchymal stromal cells	Islet β cells	TNTs	Rackham et al., 2020
Murine white adipocytes^*	Murine macrophages^*	n.s.	Brestoff et al., 2021
Human MSCs	Injured alveolar epithelial cells	Cx43-containing gap junctional channels	Huang et al., 2021
Platelets	MSCs	Dynamin-dependent clathrin-mediated endocytosis	Levoux et al., 2021
Platelets^*	MSCs^*	Dynamin-dependent clathrin-mediated endocytosis	Levoux et al., 2021
BM stromal cells	Myeloma cells	TNTs and partial cell fusion	Matula et al., 2021
Myeloma cells	BM stromal cells	TNTs and partial cell fusion	Matula et al., 2021
Murine ovarian follicles	Murine ovarian follicles	Gap junction internalization	Norris, 2021
Glioblastoma stem cells	Glioblastoma stem cells	TNTs	Pinto et al., 2021
3D-glioblastoma organoids	3D-glioblastoma organoids	TNTs	Pinto et al., 2021
Human breast epithelial cancer cells	Human breast epithelial cancer cells	ECVs	Rabas et al., 2021
Murine high-metastatic lung carcinoma cells	Murine low-metastatic lung carcinoma cells	ECVs	Takenaga et al., 2021
Murine low-metastatic lung carcinoma cells	Murine high-metastatic lung carcinoma cells	ECVs	Takenaga et al., 2021
Murine high-metastatic lung carcinoma cells^*	Murine low-metastatic lung carcinoma cells and cancer-associated fibroblasts^*	ECVs	Takenaga et al., 2021
MSCs	Neurons	Cell-to-cell contact	Tseng et al., 2021
Human glioblastoma cells	Human primary astrocytes	TNTs	Valdebenito et al., 2021
Human neurons	Human astrocytes	TNTs	Lampinen et al., 2022
Murine neurons	Murine astrocytes	TNTs	Lampinen et al., 2022
Murine brown adipocytes^*	Murine adipocytes^*	ECVs	Rosina et al., 2022
Effector immune cells	Breast cancer cells	TNTs	Saha et al., 2022
T cells^*	Lung carcinoma cells^*	TNTs	Saha et al., 2022
T cells^*	Melanoma cells^*	TNTs	Saha et al., 2022

in vivo work

Note: TNTs, nanotubes, protrusions, microtubes, actin-based intercellular structures, cellular bridges—types of filamentous tubes that function as intercellular bridges. n.s., not specified in original paper.

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