GPCRs proposed to be mechanosensitive.
| GPCR . | Other names . | Tested mechanical stimuli . |
|---|---|---|
| AT1R | Angiotensin II receptor 1 | Shear stress; cell stretch; hypoosmotic saline |
| B2R | Bradykinin receptor 2 | Shear stress; hypoosmotic saline |
| H1R | Histamine receptor 1 | Cell indentation; hypoosmotic saline |
| GPR68 | OGR1 [ovarian cancer G-protein coupled receptor 1] | Shear stress; cell stretch |
| Rh5, Rh6, NINA-E | Insect rhodopsins | Required for mechanosensory function |
| ADGRG5 | GPR114 | Centrifugation of cell suspension |
| ADGRG6 | GPR126 | Centrifugation of cell suspension; vibration of adherent cells; AFM pushing/pulling |
| ADGRG1 | GPR56 | AFM pushing/pulling |
| ADGRD1 | GPR133 | Centrifugation of cell suspension |
| ADGRL1 | Latrophilin-1, CIRL-1, CL1, dCIRL | Inferred based on role in cell–cell adhesion; required for mechanosensory function in fruit flies and nematodes |
| ADGRL2 | Latrophilin-2, CIRL-2, CL2 | |
| ADGRL3 | Ltrophilin-3, CIRL-3, CL3 |
| GPCR . | Other names . | Tested mechanical stimuli . |
|---|---|---|
| AT1R | Angiotensin II receptor 1 | Shear stress; cell stretch; hypoosmotic saline |
| B2R | Bradykinin receptor 2 | Shear stress; hypoosmotic saline |
| H1R | Histamine receptor 1 | Cell indentation; hypoosmotic saline |
| GPR68 | OGR1 [ovarian cancer G-protein coupled receptor 1] | Shear stress; cell stretch |
| Rh5, Rh6, NINA-E | Insect rhodopsins | Required for mechanosensory function |
| ADGRG5 | GPR114 | Centrifugation of cell suspension |
| ADGRG6 | GPR126 | Centrifugation of cell suspension; vibration of adherent cells; AFM pushing/pulling |
| ADGRG1 | GPR56 | AFM pushing/pulling |
| ADGRD1 | GPR133 | Centrifugation of cell suspension |
| ADGRL1 | Latrophilin-1, CIRL-1, CL1, dCIRL | Inferred based on role in cell–cell adhesion; required for mechanosensory function in fruit flies and nematodes |
| ADGRL2 | Latrophilin-2, CIRL-2, CL2 | |
| ADGRL3 | Ltrophilin-3, CIRL-3, CL3 |
Interested readers may consult these reviews for additional discussion: Liebscher et al, 2021; Lin et al, 2022a; Wilde et al, 2022.